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Pegvaliase effectively reduces blood phenylalanine levels in most PKU patients, but requires personalized plans and good communication to manage side effects.

Some nutraceuticals may help in COVID-19 prevention and treatment, but more research is needed.

Zinc is important for skin health, and supplements can help treat various skin and hair disorders, but more research is needed for conditions like psoriasis and vitiligo.

Topical corticosteroids are the main treatment for Erosive Pustular Dermatosis, but recurrence is common after stopping treatment.

JAK inhibitors can effectively reverse hair loss in people with alopecia areata.

JAK inhibitors show promise in effectively treating hair loss from alopecia areata.

Vitamin D is important for skin health, but more research is needed to understand its full effects and treatment potential.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

AE can have varied symptoms and genetic causes, but zinc therapy helps.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Recognizing LET and AITD can help diagnose SLE early for better treatment.

A young woman with severe symptoms was diagnosed with SLE and improved significantly after treatment.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

AKN is a chronic scalp condition in African-descended males, treated with topicals, antibiotics, steroids, and sometimes surgery or laser.

STK11 gene polymorphism does not predict metformin response in PCOS.

Custom software found that common allergy drugs might have new uses for various conditions and could improve survival in some cancers.

No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

Long-term use of androgens can help manage Hereditary Angioedema (HAE) but may cause serious side effects, so alternative treatments with fewer side effects are being considered.

Cyproterone acetate is effective for treating hirsutism, but some patients may feel worse on low-dose maintenance therapy.

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

COVID-19 may trigger severe skin flare-ups in people with autoimmune conditions like lupus.

Retinoids help treat psoriasis effectively, but they can cause side effects and need more research on safe use with other treatments.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

The document concludes that treating tough skin disease in lupus involves sun protection, steroids, antimalarials, and various other therapies chosen based on individual risks and benefits.

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

Different connective tissue disorders have unique symptoms and treatments, with varying outcomes and often require ongoing care from a specialist.

Various dermatologic treatments were effective for skin conditions like acne, rosacea, hair loss, and psoriasis from December 1986 to December 1987.

Clindamycin and rifampicin are the most effective treatments for folliculitis decalvans, but more research is needed.

Some vitamins and minerals are important for preventing hair loss, but treating hair loss with them without a known deficiency is not proven effective.