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    Glossary Local Signaling

    cells communicate with nearby cells using signaling molecules

    Local signaling refers to the process by which cells communicate with nearby cells through the release of signaling molecules. This type of communication is crucial for coordinating activities such as tissue repair, immune responses, and the regulation of hair growth. For example, in the context of hair biology, local signaling can influence the behavior of hair follicle cells, potentially affecting conditions like alopecia.

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    1. Local Microenvironment Provides Important Cues for Cell Differentiation in Lingual Epithelia PloS one · 2012 · 6 citations
    2. Local IL-17 orchestrates skin aging bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    3. Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream Pharmaceutics · 2021 · 24 citations
    4. 588 Skin fibroblast heterogeneity and plasticity are determined by the local niche Journal of Investigative Dermatology · 2019
    5. Principles of Hair Cycle Control The Journal of Dermatology · 1998 · 109 citations
    6. The developmental basis of fingerprint pattern formation and variation Cell · 2023 · 44 citations
    7. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021 · 22 citations
    8. Frontiers in the (Neuro-)endocrine Controls of Hair Growth Journal of Investigative Dermatology Symposium Proceedings · 2007 · 22 citations
    9. Biology of Hair Growth and Influence of External Factors (Ecology, Stress, Nutrition Universal library of medical and health sciences. · 2025
    10. Regulation and dysregulation of hair regeneration: aiming for clinical application Cell Regeneration · 2022 · 2 citations
    11. Exosomes based advancements for application in medical aesthetics Frontiers in Bioengineering and Biotechnology · 2022 · 4 citations
    12. Canonical prolactin signaling and global mRNA expression in the skin of Holstein heifers carrying the SLICK1 allele of the prolactin receptor gene Journal of Dairy Science · 2025 · 1 citations
    13. Dermal niche signaling and epidermal stem cells Advances in stem cells and their niches · 2019
    14. Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application Bioactive materials · 2023 · 2 citations
    15. Supplementary Material for: Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping Figshare · 2026
    16. 271 The role of local and systemic leptin in androgenetic alopecia Journal of Investigative Dermatology · 2017
    17. Multifunctional NIR‐Triggered Nanozyme‐Based Microneedles for Synergistic Eradication of MRSA and Enhanced Wound Healing Advanced Science · 2025 · 1 citations
    18. Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model International Journal of Molecular Sciences · 2024
    19. G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 4 citations
    20. Auxin modulates root-hair growth through its signaling pathway in citrus Scientia Horticulturae · 2018 · 28 citations
    21. Regulation of masculinization: androgen signalling for external genitalia development Nature Reviews Urology · 2018 · 45 citations
    22. Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity Frontiers in Cellular Neuroscience · 2026
    23. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice* Endocrinology · 2001 · 73 citations
    24. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001 · 14 citations
    25. Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy Journal of lasers in medical sciences · 2019 · 13 citations
    26. Pathological Skin Scarring: From Mechanism to Targeted Local Therapy Preprints.org · 2026
    27. Vascular endothelial cells as signaling niches for epithelial stem cells in the skin Frontiers in Cell and Developmental Biology · 2026
    28. Responses of hair follicle–associated structures to loss of planar cell polarity signaling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 29 citations
    29. Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Dermatological Science · 2012 · 1 citations
    30. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling Heliyon · 2017 · 3 citations