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Leflunomide is effective for rheumatoid arthritis but has significant side effects.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

High doses of certain vitamins can cause serious side effects and health risks.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Human skin can make serotonin and melatonin, which help protect and maintain it.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Coal tar shampoos, salicylic acid, and topical corticosteroids are effective for scalp psoriasis, with Vitamin D3 analogues also showing benefits; severe cases may require stronger medication with more risks.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.

Green tea may help with health issues like cancer, heart disease, and weight loss due to its high catechin content.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

EGFR-TKIs can cause significant skin, nail, and organ side effects.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Eclipta alba has many health benefits and contains compounds with potential for drug development.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Jojoba oil is highly valued for its diverse medicinal and industrial uses.

Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.

Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.