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    Did you mean Lipid Accumulation?
    Glossary Lipid Accumulation

    excessive fat build-up within cells or tissues

    Lipid accumulation, also known as fat accumulation, refers to the build-up of lipids (fats) within cells or tissues. This process can occur in various parts of the body, including the liver, muscles, and skin, and is often associated with metabolic disorders such as obesity, diabetes, and cardiovascular diseases. In the context of hair and alopecia, excessive lipid accumulation in the scalp can potentially disrupt normal hair follicle function, contributing to hair loss.

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    1. Clinical Usefulness of Non-Invasive Metabolic-Associated Fatty Liver Disease Risk Assessment Methods in Patients with Full-Blown Polycystic Ovary Syndrome in Relation to the MRI Examination with the Ideal IQ Sequence Biomedicines · 2022
    2. Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity Scientific Reports · 2025
    3. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm The World Journal of Men's Health · 2020 · 17 citations
    4. Rodent models in placental research. Implications for fetal origins of adult disease Animal Reproduction · 2022 · 7 citations
    5. Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk Genes & Development · 2007 · 102 citations
    6. Dihydroartemisinin loaded nanostructured lipid carriers (DHA-NLC): evaluation of pharmacokinetics and tissue distribution after intravenous administration to rats. PubMed · 2010 · 11 citations
    7. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5 Proceedings of the National Academy of Sciences of the United States of America · 2017 · 18 citations
    8. Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy Research Square (Research Square) · 2020
    9. Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome Journal of the Endocrine Society · 2023
    10. The Acute Toxicity of 2,3,4,7,8-Pentachlorodibenzofuran (4PeCDF) in the Male Fischer Rat Toxicological Sciences · 1988
    11. Metabolic dysfunction-associated steatotic liver disease is associated with androgenetic alopecia in adults with stronger effects in women and unhealthy lifestyles Scientific Reports · 2025
    12. Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidation Journal of Lipid Research · 1997 · 109 citations
    13. Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction Hormone Molecular Biology and Clinical Investigation · 2017 · 20 citations
    14. Metabolic syndrome – a new definition and management guidelines A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, “Club 30” Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons Archives of Medical Science · 2022 · 20 citations
    15. The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation Biomedicines · 2022
    16. Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men Advances in Experimental Medicine and Biology · 2017 · 31 citations
    17. Elevated fasting insulin is associated with cardiovascular and metabolic risk in women with polycystic ovary syndrome Diabetes and Metabolic Syndrome: Clinical Research and Reviews · 2019 · 17 citations
    18. Metabolic dysfunction in female mice with disruption of 5α-reductase 1 2017 · 11 citations
    19. Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle Histochemistry and Cell Biology · 2021 · 13 citations
    20. Unravelling the link between insulin resistance and androgen excess University of Birmingham Institutional Research Archive (University of Birmingham) · 2015
    21. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014 · 88 citations
    22. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports · 2017 · 20 citations
    23. Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow Cell regeneration · 2020 · 6 citations
    24. Metabolic Aspects of Polycystic Ovary Syndrome Postgraduate obstetrics & gynecology · 2015
    25. Tissue fibrosis associated depletion of lipid‐filled cells Experimental Dermatology · 2024 · 6 citations
    26. Clinical aspects of the metabolic syndrome 2017
    27. The expression of the gene <i>asebia</i> in the laboratory mouse: 3. Sebaceous glands Genetics Research · 1978 · 16 citations
    28. Protoporphyrin IX: the Good, the Bad, and the Ugly Journal of Pharmacology and Experimental Therapeutics · 2015 · 138 citations
    29. Marine Health-Promoting Compounds: Recent Trends for Their Characterization and Human Applications Foods · 2021 · 18 citations
    30. Effects of α-Synuclein on the Lipid Phenotype of SZ95 Human Sebocytes: A Preliminary Study in the Context of Parkinson’s Disease Cells · 2026