550 citations
,
January 2012 in “Oxford University Research Archive (ORA) (University of Oxford)” This study found that lithium treatment for mood disorders is associated with risks of hypothyroidism, hyperparathyroidism, and reduced urinary concentrating ability, but the risk of significant renal failure is low.
65 citations
,
July 2013 in “International Clinical Psychopharmacology” This review provides an overview of the prevalence and management of side effects of mood-stabilizing drugs in bipolar disorder patients and reports no new clinical results.
64 citations
,
February 1995 in “Journal of The American Academy of Dermatology” This report describes a case where hidradenitis suppurativa developed in a patient receiving lithium, adding to the recognized cutaneous side effects like psoriasis, acneiform lesions, and alopecia.
29 citations
,
July 1982 in “British Journal of Dermatology” This article discusses hair loss linked to lithium treatment but reports no new clinical findings.
28 citations
,
October 1987 in “PubMed” This study found that treating Tradescantia stamen hair cells with LiCl disrupts mitotic progression, leading to metaphase arrest, which can be reversed by myo-inositol or CaCl2 addition.
18 citations
,
October 1984 in “International Journal of Dermatology” This article reviews the relationship between hair loss and lithium but does not provide any new clinical findings.
17 citations
,
February 2001 in “Journal of the American Academy of Dermatology” This case report suggests that lithium, either alone or with haloperidol, may induce skin changes resembling follicular mycosis fungoides.
16 citations
,
July 2014 in “Cell Biology International” This study found that the Wnt pathway activator lithium chloride promotes proliferation and odontoblast differentiation of hair follicle neural crest cells.
14 citations
,
December 2017 in “Journal of Intensive Care” Lithium poisoning can cause severe health complications and requires careful monitoring.
2 citations
,
January 2015 in “Chinese Medical Journal” In this case report, purpura was associated with lithium treatment at therapeutic levels, highlighting the importance of monitoring for symptoms of intoxication even when lithium concentrations appear normal.
2 citations
,
January 2007 in “Toxicologie Analytique et Clinique” This case study observed a massive lithium overdose in a 38-year-old woman with bipolar disorder, who survived despite extremely high lithium concentrations through continuous venovenous hemodiafiltration.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that the combination of lithium and zinc demonstrated significant transcriptomic rescue in three datasets, with consistent results across methodologies, suggesting its potential targeting of DP-specific pathways.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that the combination of lithium and zinc produced a statistically significant transcriptomic rescue across three datasets, with the strongest signal observed in a DP-enriched model, suggesting potential efficacy in targeting DP-specific pathways.
This review suggests that lithium can lead to sexual dysfunction, hair loss, acne, and psoriasis in some patients, highlighting potential management strategies but noting the need for further research.
January 2015 in “International Journal of Trichology” Lithium can treat bipolar disorder but may cause hair loss and other hair problems.
September 2025 in “Stem Cells Translational Medicine” This study found that exosomes from human umbilical cord stem cells, pretreated with lithium chloride, significantly enhance hair regeneration in mice by activating the Wnt signaling pathway through miR-146a-5p.
January 2025 in “Exploratory Animal and Medical Research” Among adult male rats, this study found that combined exposure to lithium carbonate and lead acetate over 28 days led to synergistic cardiotoxic effects, evidenced by oxidative stress, ECG abnormalities, and molecular markers of increased apoptosis, despite no observable structural damage to myocardial tissue.
293 citations
,
September 2004 in “Development” This study found that WNT signaling is essential for the initiation of mammary gland morphogenesis in embryonic mice, promoting placode development and potentially playing a critical role in skin appendage formation.
113 citations
,
June 2015 in “Stem Cell Research & Therapy” This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.
79 citations
,
January 2000 in “Annals of Clinical Psychiatry” This review discusses the potential for mood stabilizers, antidepressants, and some antipsychotic and antianxiety drugs to induce alopecia and reports no clinical results.
74 citations
,
January 2014 in “Journal of Investigative Dermatology” High kallistatin levels in diabetics worsen wound healing by blocking important cell signals.
63 citations
,
March 2000 in “Annals of clinical psychiatry” This article reviews the association between psychopharmaceuticals and medication-induced alopecia, noting that hair regrowth typically occurs after discontinuing or reducing the medication, while mineral supplements' effectiveness remains unclear.
52 citations
,
October 2016 in “Clinics in Dermatology” This review discusses various drugs that can cause drug-induced acne, noting specific clinical and histopathologic features, but reports no new clinical findings.
38 citations
,
September 1996 in “Annals of Clinical Psychiatry” This review discusses the association between mood stabilizers and alopecia, providing diagnosis insights and management options, but reports no new clinical results.
31 citations
,
October 2013 in “Psychosomatics” This review discusses cutaneous adverse effects of psychotropic medications and reports no new findings, emphasizing the importance of psychiatrists being aware of these potential skin reactions.
30 citations
,
May 1991 in “Psychosomatics” This review examines alopecia as a side effect of psychotropic medications, noting that it is typically reversible after stopping the drug, but it reports no new results.
24 citations
,
January 2019 in “Science China Life Sciences” Chitosan/LiCl composite scaffolds help heal deep skin wounds better.
20 citations
,
September 1995 in “PubMed” This review discusses the wide range of drugs potentially causing reversible or irreversible hair loss and emphasizes the difficulty of diagnosing drug-induced alopecia without withdrawal of the suspected medication; it reports no new clinical findings.
19 citations
,
May 2020 in “Cells” This study found that 5% primed conditioned medium from human umbilical cord blood-derived mesenchymal stromal cells significantly improved hair density, thickness, and growth rate in patients with androgenetic alopecia.
14 citations
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May 2005 in “Farmaco” This study developed a high performance capillary electrophoresis method, validated for both legal and illicit minoxidil-based products, to confirm minoxidil's presence alongside known impurities.