research Skin l‐tryptophan‐2,3‐dioxygenase and rat hair growth
This study identified a new enzyme, skin l‐tryptophan‐2,3‐dioxygenase, that may play a role in rat hair growth regulation, showing increased activity during peak hair growth periods.
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research Scleroderma and L-tryptophan: A possible explanation of the eosinophilia-myalgia syndrome
This study reports that six women developed scleroderma while taking L-tryptophan and showed improvement after stopping the supplement and/or starting corticosteroid therapy.
research Cutaneous Mucinosis in a Patient With Eosinophilia-Myalgia Syndrome Associated With L-Tryptophan Ingestion
This case report describes a patient with eosinophilia-myalgia syndrome, likely linked to L-tryptophan use, who developed a skin rash characterized by cutaneous mucinosis.
research On the Role of Melatonin in Skin Physiology and Pathology
This article discusses the potential role of melatonin in protecting skin against stress and maintaining homeostasis, based on its local synthesis and various protective functions, but presents no new clinical results.
research Riboflavin-responsive glutaryl CoA dehydrogenase deficiency
This study reports that riboflavin may increase enzymatic activity in a GCDH-deficient patient with specific mutations, but doesn't fully normalize urinary organic acid levels.
research Dermal Mucinosis in the Eosinophilia-Myalgia Syndrome
This case report details a woman with eosinophilia-myalgia syndrome associated with L-tryptophan ingestion, highlighting skin lesions with abundant dermal mucin.
research Telogen effluvium associated with eosinophilia-myalgia syndrome
This case report describes a patient with eosinophilia-myalgia syndrome who experienced severe, persistent telogen effluvium.
research The eosinophilia-myalgia syndrome
This review discusses the emergence and impact of eosinophilia-myalgia syndrome related to L-tryptophan and offers insights into environmental factors affecting sclerodermatous conditions, with no new research findings presented.
research Indole-based derivatives effect on rats with polycystic ovary syndrome
In this study, the administration of indole-based compounds, particularly L-Tryptophan and Tryptophol, to a PCOS-induced rat model resulted in an increased number of healthy ovarian follicles and a reduction in ovarian cysts compared to untreated rats, suggesting potential therapeutic efficacy.
research High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase
This study reports that mutations in human L-PGDS affect the entrance and exit of ligands in its binding cavity, suggesting these residues play a role in ligand interaction processes.
research Comparison of the Pathology of Fascia in Eosinophilic Myalgia Syndrome Patients and Idiopathic Eosinophilic Fasciitis
In this study, researchers found histopathological similarities between L-tryptophan eosinophilic myalgia syndrome and idiopathic eosinophilic fasciitis, with certain unique inflammatory features present in the former.
research A patient with eosinophilia-myalgia syndrome.
This case report describes a patient with eosinophilia-myalgia syndrome related to L-tryptophan use, detailing the specific symptoms and laboratory abnormalities observed.
research Design, Synthesis and Anxiolytic Activity Evaluation of N-Acyltryptophanyl- Containing Dipeptides, Potential TSPO Ligands#
The authors concluded that newly synthesized N-acyl-L-tryptophanyl-isoleucine amides showed high anxiolytic activity in animal models, comparable to diazepam, through interaction with the TSPO receptor.
research Eosinophilic Fasciitis Associated With Tryptophan Ingestion
In this study, researchers found that high-dose tryptophan ingestion before symptom onset may be linked to clinical features resembling eosinophilia-myalgia syndrome in patients with eosinophilic fasciitis.
research Dietary supplementation with L-glutamine enhances immunity and reduces heat stress in Hanwoo steers under heat stress conditions
This study found that L-glutamine supplementation in Hanwoo steers under heat stress did not affect growth performance or muscle and adipose tissue gene expression but was associated with increased immune cells and reduced HSP90 expression.
research Reduction mechanism of L‐cysteine on keratin fibers using microspectrophotometry and Raman spectroscopy
In this study, researchers found that L-cysteine interacted electrostatically with anionic ions on the surface of keratin fibers in human hair, reducing the rate of disulfide bond disconnection at pH 9.0.
research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction
This study found that both finasteride and dutasteride significantly reduced L-DOPA-induced dyskinesia in a rat model of Parkinson's disease, with dutasteride showing greater effectiveness at lower doses.
research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family
This study explored the structure and function of lipocalin prostaglandin D synthase, revealing its dual role in substrate catalysis and as a lipophilic ligand carrier, potentially informing future drug delivery design.
research NIGELLA SATIVA L.: AN OVERVIEW
This review highlights Nigella sativa L. (black cumin) as a plant with numerous health benefits, noting its rich nutritional profile and reported therapeutic effects such as antioxidant and anti-inflammatory activities, identified through various in vitro, in vivo, and clinical research studies.
research Graphene oxide and indole-3-acetic acid cotreatment regulates the root growth of Brassica napus L. via multiple phytohormone pathways
This study found that cotreatment with graphene oxide and indole-3-acetic acid significantly inhibited root development in Brassica napus, with the inhibition increasing as indole-3-acetic acid concentration rose.
research The coudability sign of alopecia areata: the real story
This paper discusses the concept of "coudability," a characteristic of alopecia areata, and provides a historical perspective, but it reports no new clinical results.
research Promotion of Hair Growth by Applying Sulfur Amino Acids and Other Things to the Skin
In this study, L-methionine and L-serine application was observed to have the most significant effect on hair weight and root length, followed by acetyl L-methionine and L-serine, while glutathione inhibited growth.
research HPLC-ESI-MSn characterization of phenolic compounds, terpenoid saponins, and other minor compounds in Bituminaria bituminosa
This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.
research Adverse cutaneous reactions to chemotherapeutic agents and cytokine therapy
This article reviews adverse skin reactions caused by chemotherapy and cytokine treatments, describing specific and nonspecific reactions, but reports no new clinical findings.
research Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching
This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.
research Internal structure changes in bleached black human hair resulting from chemical treatments: A Raman spectroscopic investigation
In this study, the authors concluded that a hydrolyzed eggwhite protein treatment promoted the reconnection of disulfide bonds in excessively bleached hair, after reduction and oxidation processes in permanent waving.
research Influence of Amino Acids on the Hair Structure Before and During Chemical Treatments
This study analyzes contemporary theories and practices to understand key factors influencing the development of the examined phenomenon, proposing trends and practical applications for researchers and practitioners, while acknowledging study limitations and suggesting future research directions.
research Serotoninergic and melatoninergic systems are fully expressed in human skin
This study provides evidence that human skin contains genes and enzymes necessary for producing serotonin and melatonin.
research Tryptophan in human hair: correlation with pigmentation
This study observed that tryptophan levels in human hair are higher in males than females, increase with age, and vary with hair color, being highest in grey and white hair.
research Are Women with Polycystic Ovary Syndrome at Increased Risk of Alzheimer Disease? Lessons from Insulin Resistance, Tryptophan and Gonadotropin Disturbances and Their Link with Amyloid-Beta Aggregation
This review suggests systemic changes in polycystic ovary syndrome may increase the risk of neurodegeneration, potentially linking it to Alzheimer's disease through common pathways affecting tryptophan metabolism.