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    Glossary Keratin

    protein forming hair, nails, and skin's outer layer

    Keratin is a type of protein that forms the structural foundation of hair, nails, and the outer layer of skin. It provides strength and protection, making these tissues resilient and less prone to damage. In hair, keratins are essential for maintaining its integrity and elasticity, and they play a crucial role in the hair's overall health and appearance.

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    1. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    2. ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments Current Opinion in Cell Biology · 2002 · 686 citations
    3. A Review of Keratin-Based Biomaterials for Biomedical Applications Materials · 2010 · 517 citations
    4. Keratin cytoskeletons in epithelial cells of internal organs Proceedings of the National Academy of Sciences · 1979 · 482 citations
    5. Keratins in health and cancer: more than mere epithelial cell markers Oncogene · 2010 · 438 citations
    6. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves Biomaterials · 2007 · 309 citations
    7. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    8. Keratins of the Human Hair Follicle International review of cytology · 2005 · 276 citations
    9. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001 · 272 citations
    10. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins. Journal of Investigative Dermatology · 1989 · 238 citations
    11. The Catalog of Human Hair Keratins 1999 · 235 citations
    12. Human Hair Keratin‐Associated Proteins (KAPs) International review of cytology · 2006 · 226 citations
    13. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018 · 211 citations
    14. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology · 1989 · 198 citations
    15. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    16. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019 · 192 citations
    17. The expanding significance of keratin intermediate filaments in normal and diseased epithelia Current opinion in cell biology · 2012 · 186 citations
    18. Keratin gene mutations in disorders of human skin and its appendages Archives of Biochemistry and Biophysics · 2010 · 185 citations
    19. Keratin 17 modulates hair follicle cycling in a TN<i>Fα</i>-dependent fashion Genes & Development · 2006 · 169 citations
    20. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development · 1989 · 156 citations
    21. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes & Development · 1992 · 150 citations
    22. Hair follicle-specific keratins and their diseases Experimental cell research · 2007 · 138 citations
    23. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    24. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    25. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    26. Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation Experimental Cell Research · 1989 · 128 citations
    27. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    28. Chapter 2 The Human Keratin Genes and Their Differential Expression 1987 · 126 citations
    29. Keratin 17 null mice exhibit age- and strain-dependent alopecia Genes & Development · 2002 · 122 citations
    30. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair BMC Evolutionary Biology · 2008 · 119 citations