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    Glossary Keratin

    protein forming hair, nails, and skin's outer layer

    Keratin is a type of protein that forms the structural foundation of hair, nails, and the outer layer of skin. It provides strength and protection, making these tissues resilient and less prone to damage. In hair, keratins are essential for maintaining its integrity and elasticity, and they play a crucial role in the hair's overall health and appearance.

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    1. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    2. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons Proceedings of the National Academy of Sciences · 2005 · 419 citations
    3. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    4. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    5. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019 · 192 citations
    6. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013 · 85 citations
    7. Structural change of keratin protein in human hair by permanent waving treatment Polymer · 1998 · 70 citations
    8. Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin. PubMed · 1999 · 54 citations
    9. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    10. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    11. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse Molecular Carcinogenesis · 2012 · 44 citations
    12. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    13. Keratin intermediate filaments in the colon: guardians of epithelial homeostasis International journal of biochemistry & cell biology · 2020 · 38 citations
    14. Keratin Expression Provides Novel Insight into the Morphogenesis and Function of the Companion Layer in Hair Follicles Journal of Investigative Dermatology · 2006 · 38 citations
    15. Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling PloS one · 2012 · 35 citations
    16. Development, Structure, and Keratin Expression in <i>C57BL/6J</i> Mouse Eccrine Glands Veterinary pathology · 2011 · 29 citations
    17. Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia International Journal of Molecular Medicine · 2012 · 28 citations
    18. Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes Biochemical and Biophysical Research Communications · 2000 · 12 citations
    19. A new tool for conditional gene manipulation in a subset of keratin‐expressing epithelia Genesis · 2012 · 4 citations
    20. A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms International journal of molecular sciences · 2023 · 3 citations
    21. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    22. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    23. An Investigation of Keratin 15 Function by Small Interfering Ribonucleic Acid Technology Durham e-Theses (Durham University) · 2012
    24. Expression of Keratin 15 in Alopecia's Frontal Hair Follicle Zhongguo linchuang yixue · 2007
    25. ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments Current Opinion in Cell Biology · 2002 · 686 citations
    26. A Review of Keratin-Based Biomaterials for Biomedical Applications Materials · 2010 · 517 citations
    27. Keratin cytoskeletons in epithelial cells of internal organs Proceedings of the National Academy of Sciences · 1979 · 482 citations
    28. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage Journal of Cell Science · 1996 · 441 citations
    29. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development The Journal of Cell Biology · 1998 · 318 citations
    30. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves Biomaterials · 2007 · 309 citations