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    Glossary Keratin 17

    protein crucial for skin, hair, and nail structure

    Keratin 17 (K17) is a type of protein found in the skin, hair follicles, and nails, playing a crucial role in their structural integrity and resilience. It is also involved in cellular processes like growth and repair, and its abnormal expression is linked to certain skin disorders and cancers.

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    1. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development The Journal of Cell Biology · 1998 · 318 citations
    2. Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2 British Journal of Dermatology · 1998 · 175 citations
    3. Keratin 17 modulates hair follicle cycling in a TN<i>Fα</i>-dependent fashion Genes & Development · 2006 · 169 citations
    4. Keratin 17 null mice exhibit age- and strain-dependent alopecia Genes & Development · 2002 · 122 citations
    5. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000 · 88 citations
    6. Keratin 17 Gene Expression during the Murine Hair Cycle Journal of Investigative Dermatology · 1997 · 70 citations
    7. Keratin 17 in disease pathogenesis: from cancer to dermatoses Journal of pathology · 2018 · 62 citations
    8. Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005 · 58 citations
    9. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    10. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion 2011 · 30 citations
    11. Psoriasis patients demonstrate HLA-Cw*06:02 allele dosage-dependent T cell proliferation when treated with hair follicle-derived keratin 17 protein Scientific Reports · 2018 · 27 citations
    12. Homozygous Dominant Missense Mutation in Keratin 17 Leads to Alopecia in Addition to Severe Pachyonychia Congenita Journal of Investigative Dermatology · 2012 · 22 citations
    13. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis Journal of Investigative Dermatology · 2015 · 19 citations
    14. <i>In vivo</i> alteration of the keratin 17 gene in hair follicles by oligonucleotide‐directed gene targeting Experimental Dermatology · 2003 · 8 citations
    15. Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation–Induced Skin Damage 2023 · 3 citations
    16. KERATIN 17-related recessive atypical pachyonychia congenita with variable hair and tooth anomalies European journal of human genetics · 2022 · 3 citations
    17. In vivo Alteration of the Keratin 17 Gene in Hair Follicles by Oligonucleotide-directed Gene Targeting Chinese Journal of Dermatology · 2004
    18. A group of type I keratin genes on human chromosome 17: characterization and expression. Molecular and Cellular Biology · 1988 · 141 citations
    19. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    20. Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino-Acid Composition and Repeat Structure 2007 · 51 citations
    21. Variation in the caprine keratin-associated protein 15-1 (KAP15-1) gene affects cashmere fibre diameter 2019 · 30 citations
    22. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits Animals · 2019 · 7 citations
    23. Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1 2022
    24. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988 · 38 citations
    25. Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair-Follicle-Derived Tumors in Comparison with Nonfollicular Epithelial Skin Tumors Journal of Investigative Dermatology · 1995 · 31 citations
    26. The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain Differentiation · 2004 · 70 citations
    27. Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits Genes · 2017 · 29 citations
    28. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    29. A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21. Journal of Medical Genetics · 1994 · 61 citations
    30. Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings Current Issues in Molecular Biology · 2024 · 37 citations