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    Glossary Keratin 14

    protein in skin's basal layer providing structural support

    Keratin 14 (KRT14) is a type of protein found in the skin, specifically in the basal layer of the epidermis. It plays a crucial role in providing structural support and resilience to skin cells. Mutations in the KRT14 gene can lead to skin disorders such as epidermolysis bullosa simplex, which causes the skin to be fragile and blister easily.

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    1. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    2. Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 1991 · 38 citations
    3. Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases International Journal of Dermatology · 2015 · 15 citations
    4. 474 Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility Journal of Investigative Dermatology · 2017
    5. Keratin 14 in skin and hair follicle of rats during postnatal development period Acta Academiae Medicine Militaris Tertiae · 2001
    6. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    7. Variation in the ovine keratin-associated protein 15-1 gene affects wool yield The Journal of Agricultural Science · 2018 · 18 citations
    8. A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells PLoS ONE · 2015 · 14 citations
    9. Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits Genes · 2017 · 29 citations
    10. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    11. Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development Archives of Dermatological Research · 2013 · 19 citations
    12. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    13. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes & Development · 1992 · 150 citations
    14. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    15. The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties Journal of Biological Chemistry · 1998 · 46 citations
    16. Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex International Journal of Molecular Sciences · 2021 · 40 citations
    17. Identification of somatic and germline mosaicism for a keratin 5 mutation in epidermolysis bullosa simplex in a family of which the proband was previously regarded as a sporadic case Clinical Genetics · 2004 · 26 citations
    18. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016 · 14 citations
    19. KERATIN PHENOTYPES IN BASAL-CELL CARCINOMAS OF THE SKIN International Journal of Oncology · 1993 · 7 citations
    20. Development of a mechanically stable human hair keratin film for cell culture Materials today communications · 2021 · 3 citations
    21. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    22. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    23. 1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth 2023
    24. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    25. Against the Rules: Human Keratin K80 Journal of Biological Chemistry · 2010 · 40 citations
    26. Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine Genes · 2019 · 24 citations
    27. Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammals 2005 · 21 citations
    28. Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification International Journal of Dermatology · 2013 · 12 citations
    29. Keratin 79 is a PPARA target that is highly expressed by liver damage Biochemical and biophysical research communications · 2023 · 1 citations
    30. Keratin nanoparticle-loaded hydrogel microneedles for programmed repair of radiation-induced skin injury Journal of Materials Chemistry B · 2026