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GlossaryJAK-STAT pathway

transmits signals from cell surface to nucleus for gene expression

The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

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research Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

55 citations, October 2019 in “Dermatology and therapy”

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

research An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata

40 citations, August 2022 in “Frontiers in immunology”

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations, April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

research Targeting JAK/STAT and Wnt/Beta-Catenin Pathways and 5-Alpha-Reductase Activity to Develop an Effective Anti-Hair Loss Product

November 2022 in “Journal of Investigative Dermatology”

The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

research The JAK/STAT Signaling Pathway: From Bench to Clinic

489 citations, November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

May 2024 in “Archives of dermatological research”

Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.

research Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

2 citations, April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research Oncostatin M Is Upstream of JAK-STAT Signaling During the Murine Hair Cycle

April 2016 in “Journal of Investigative Dermatology”

Blocking Oncostatin M's role in the JAK-STAT pathway can stimulate hair growth in mice.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

51 citations, October 2019 in “Cells”

Baricitinib reduces inflammation and improves cell health in premature aging cells.

research Small Molecule Inhibitors and Inflammatory Skin Diseases

March 2018 in “Suez Canal University Medical Journal”

New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

research JAK Inhibitors: New Players in the Field of Immune-Mediated Diseases Beyond Rheumatoid Arthritis

223 citations, September 2018 in “Rheumatology”

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

research Efficacy of JAK 1/2 Inhibition in the Treatment of Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus

16 citations, January 2020 in “Annals of the rheumatic diseases”

Baricitinib might help treat hair loss in lupus patients, but more research is needed.

research Under Development JAK Inhibitors for Dermatologic Diseases

14 citations, January 2020 in “Mediterranean Journal of Rheumatology”

New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.

research Alopecia Areata: Case Report and Review of Pathophysiology and Treatment with JAK Inhibitors

6 citations, November 2022 in “Journal of autoimmunity”

JAK inhibitors like tofacitinib may effectively treat Alopecia Areata.

research Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo

March 2017 in “Current dermatology reports”

Topical JAK inhibitors can effectively treat alopecia areata and vitiligo by modulating immune responses.

research Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature

40 citations, December 2016 in “Journal of Dermatological Treatment”

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

research Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

3 citations, July 2023 in “International journal of molecular sciences”

Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.

research Molecular Basis of Hair Follicle Donor Dominance in Androgenetic Alopecia and Sexual Dimorphism of the Skin

April 2017 in “Journal of Investigative Dermatology”

Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib

13 citations, January 2020 in “Acta Dermato Venereologica”

Ruxolitinib treatment led to unexpected hair regrowth in a patient with alopecia universalis.

research Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms

13 citations, February 2010 in “Stem Cell Reviews and Reports”

Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.

research Recalcitrant Alopecia Areata Responsive to Leflunomide and Anthralin—Potentially Undiscovered JAK/STAT Inhibitors?

11 citations, October 2018 in “Pediatric dermatology”

Leflunomide and anthralin may effectively treat severe alopecia areata.