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    Did you mean JAK-STAT pathway?
    Glossary JAK-STAT pathway

    transmits signals from cell surface to nucleus for gene expression

    The JAK-STAT pathway, short for Janus kinase-signal transducer and activator of transcription pathway, is a chain of interactions between proteins in a cell that transmits signals from chemical signals outside the cell to the cell nucleus, resulting in DNA transcription and activity changes. This pathway is crucial for regulating immune function, cell growth, and development, and has been implicated in various diseases, including certain types of alopecia and cancers.

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    1. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    2. Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata Dermatology and therapy · 2019 · 55 citations
    3. An overview of JAK/STAT pathways and JAK inhibition in alopecia areata Frontiers in immunology · 2022 · 40 citations
    4. Drugs targeting the JAK/STAT pathway for the treatment of immune-mediated inflammatory skin diseases: protocol for a scoping review BMJ Open · 2019 · 17 citations
    5. Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles International journal of molecular sciences · 2021 · 14 citations
    6. 570 Targeting JAK/STAT and Wnt/b-catenin pathways and 5a-reductase activity to develop an effective anti-hair loss product Journal of Investigative Dermatology · 2022
    7. JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases Frontiers in Immunology · 2026
    8. 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways 2022
    9. The JAK/STAT signaling pathway: from bench to clinic Signal Transduction and Targeted Therapy · 2021 · 489 citations
    10. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    11. Pharmacologic inhibition of JAK-STAT signaling promotes hair growth Science Advances · 2015 · 159 citations
    12. Recalcitrant alopecia areata responsive to leflunomide and anthralin—Potentially undiscovered JAK/STAT inhibitors? Pediatric dermatology · 2018 · 11 citations
    13. Ruxolitinib reverses alopecia areata via a triple mechanism: JAK-STAT inhibition, localized oxidative stress attenuation and selective apoptosis modulation Journal of Translational Autoimmunity · 2026
    14. Baricitinib-loaded EVs promote alopecia areata mouse hair regrowth by reducing JAK-STAT-mediated inflammation and promoting hair follicle regeneration Drug Discoveries & Therapeutics · 2024
    15. Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling International Journal of Molecular Sciences · 2026
    16. JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis Rheumatology · 2018 · 223 citations
    17. Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis Scientific Reports · 2021 · 36 citations
    18. Inhibidores de JAK: usos en dermatología. Parte 1: generalidades, aplicaciones en vitíligo y en alopecia areata Actas Dermo-Sifiliográficas · 2020 · 20 citations
    19. Efficacy of JAK 1/2 inhibition in the treatment of diffuse non-scarring alopecia due to systemic lupus erythematosus Annals of the rheumatic diseases · 2020 · 16 citations
    20. Under Development JAK Inhibitors for Dermatologic Diseases Mediterranean Journal of Rheumatology · 2020 · 14 citations
    21. JAK Inhibitors: A New Weapon in the Skin Care Providers' Arsenal. PubMed · 2023 · 8 citations
    22. Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors Journal of autoimmunity · 2022 · 6 citations
    23. Distinctive T Cell Patterns Defining Lymphocytic Alopecia and Alternate Autoimmune and Stem Cell Pathways, Linked to Pleiotropic Functions of Regulatory T Cells Within iSALT American Journal of Dermatopathology · 2026
    24. Jak inhibitors in the treatment of alopecia areata - a literature review Journal of Education Health and Sport · 2025
    25. El papel de los inhibidores de JAK en la alopecia areata: revisión de la literatura Revista Medicina Cutánea Ibero-Latino-Americana · 2022
    26. Topical JAK Inhibitors for the Treatment of Alopecia Areata and Vitiligo Current dermatology reports · 2017
    27. APECED: JAK Inhibition in an Adult Case with Long-Term Follow-up Journal of Human Immunity · 2025
    28. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    29. Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways International journal of molecular sciences · 2023 · 3 citations
    30. The Role of JAK Inhibitors in Atopic Dermatitis, Alopecia Areata, and Vitiligo: A Review article Saudi Medical Horizons Journal · 2026