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    Glossary Isotretinoin

    oral medication for severe acne unresponsive to other treatments

    Isotretinoin, also known by brand names like Accutane, is a powerful oral medication primarily used to treat severe acne that hasn't responded to other treatments. It works by reducing the amount of oil released by oil glands in your skin, helping your skin renew itself more quickly. While highly effective, it can have significant side effects and is typically prescribed under strict medical supervision.

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    1. Action of isotretinoin in acne rosacea and gram-negative folliculitis Journal of The American Academy of Dermatology · 1982 · 175 citations
    2. Isotretinoin treatment of acne and related disorders: An update Journal of The American Academy of Dermatology · 1983 · 126 citations
    3. Adverse effects of isotretinoin: A retrospective review of 1743 patients started on isotretinoin Australasian Journal of Dermatology · 2010 · 121 citations
    4. Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010 British Journal of Dermatology · 2010 · 98 citations
    5. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity Acta dermato-venereologica · 2017 · 66 citations
    6. Oral isotretinoin for acne Cochrane library · 2018 · 58 citations
    7. Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases International journal of risk & safety in medicine · 2018 · 54 citations
    8. Actions of isotretinoin and etretinate on the pilosebaceous unit Journal of the American Academy of Dermatology · 1982 · 46 citations
    9. Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi PLoS neglected tropical diseases · 2017 · 41 citations
    10. Avaliação dos efeitos adversos clínicos e alterações laboratoriais em pacientes com acne vulgar tratados com isotretinoína oral Anais Brasileiros de Dermatologia · 2010 · 41 citations
    11. Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin Postepy Dermatologii I Alergologii · 2013 · 37 citations
    12. Yellow facial papules associated with frontal fibrosing alopecia: A distinct histologic pattern and response to isotretinoin Journal of the American Academy of Dermatology · 2017 · 32 citations
    13. Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases. PubMed · 2017 · 26 citations
    14. Isotretinoin treatment for folliculitis decalvans: a retrospective case‐series study International Journal of Dermatology · 2018 · 23 citations
    15. Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology Anais Brasileiros de Dermatologia · 2020 · 22 citations
    16. Successful treatment of perifolliculitis capitis abscedens et suffodiens with combined isotretinoin and dapsone JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2007 · 22 citations
    17. Teratogenic effect of isotretinoin in both fertile females and males (Review) Experimental and Therapeutic Medicine · 2021 · 19 citations
    18. Insulin sensitivity, androgens and isotretinoin therapy in women with severe acne Journal of Dermatological Treatment · 2012 · 19 citations
    19. Combination of Low-Dose Isotretinoin and Pulsed Oral Azithromycin in the Management of Moderate to Severe Acne Clinical Drug Investigation · 2011 · 18 citations
    20. Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients Advances in Dermatology and Allergology · 2016 · 17 citations
    21. Asynchronous telemedicine for isotretinoin management: A direct care pilot Journal of the American Academy of Dermatology · 2021 · 16 citations
    22. Dissecting Cellulitis of the Scalp with Excellent Response to Isotretinoin Pediatric Dermatology · 2017 · 16 citations
    23. Evaluation of ovarian reserve and function in female patients treated with oral isotretinoin for severe acne: an exploratory study Cutaneous and Ocular Toxicology · 2014 · 13 citations
    24. Analyzing the Efficacy of Isotretinoin in Treating Dissecting Cellulitis: A Literature Review and Meta-Analysis Drugs in R&D · 2021 · 12 citations
    25. Oral Isotretinoin in HIV-Positive Women with Acne: Report of Three Cases Dermatology · 1998 · 11 citations
    26. Optimal laboratory testing protocol for patients with acne taking oral isotretinoin World Journal of Clinical Cases · 2023 · 9 citations
    27. Effects of isotretinoin on the hair cycle Journal of Cosmetic Dermatology · 2018 · 9 citations
    28. Fractional ablative CO<sub>2</sub> laser and oral isotretinoin—A prospective randomized controlled split‐face trial comparing concurrent versus delayed laser treatment for acne scars Lasers in Surgery and Medicine · 2023 · 8 citations
    29. Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin The international journal of risk and safety in medicine · 2021 · 8 citations
    30. Heat Enhanced Follicular Delivery of Isotretinoin to the Skin Pharmaceutical research · 2019 · 8 citations