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    Glossary Intestinal Stem Cells

    specialized cells in the gut that regenerate intestinal lining

    Intestinal Stem Cells (ISCs) are specialized cells located in the lining of the intestines that have the ability to self-renew and differentiate into various types of cells that make up the intestinal epithelium. These cells are crucial for maintaining the integrity and function of the gut by continuously replenishing the intestinal lining, which is constantly being worn down by digestive processes.

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    1. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments Nature Reviews Molecular Cell Biology · 2015 · 137 citations
    2. NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor The EMBO Journal · 2019 · 91 citations
    3. Intestinal Stem Cell Imaging in Colorectal Cancer Screening Journal of Stem Cells and Regenerative Medicine · 2013 · 3 citations
    4. Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury. bioRxiv (Cold Spring Harbor Laboratory) · 2021
    5. MEX3A regulates <i>Lgr5</i> <sup>+</sup> stem cell maintenance in the developing intestinal epithelium EMBO Reports · 2020 · 27 citations
    6. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues The Journal of Physiology · 2015 · 8 citations
    7. Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischaemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model Research Square (Research Square) · 2022
    8. Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model Frontiers in Cell and Developmental Biology · 2022 · 6 citations
    9. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009 · 326 citations
    10. Transplantation of bone mesenchymal stem cells effectively promotes intestine regeneration to eliminate endotoxemia and reduce mortality in the animal model of acute liver failure Research Square (Research Square) · 2020
    11. Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury Nature Communications · 2021 · 57 citations
    12. Compartmentalized organization: a common and required feature of stem cell niches? Development · 2010 · 63 citations
    13. Dormancy in the stem cell niche Stem Cell Research & Therapy · 2012 · 29 citations
    14. Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging Cell Stem Cell · 2014 · 17 citations
    15. Metabolic Teamwork in the Stem Cell Niche Cell metabolism · 2017 · 14 citations
    16. Stem cell niche: from concept to reality Pigment Cell & Melanoma Research · 2012 · 1 citations
    17. 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs Journal of Investigative Dermatology · 2022
    18. Stem and cancer cells Wnt long telomeres Nature Cell Biology · 2012
    19. Stem Cells in the Body 2017
    20. Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair Stem Cell Reviews and Reports · 2016 · 24 citations
    21. Small Intestinal Organoid-Derived SP Cells Contribute to Repair of Irradiation-Induced Skin Injury Stem Cells and Development · 2005 · 11 citations
    22. New insights into the role of Runx1 in epithelial stem cell biology and pathology Journal of Cellular Biochemistry · 2012 · 63 citations
    23. Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media Tissue Engineering Part A · 2010 · 50 citations
    24. Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate Genes · 2019 · 28 citations
    25. Abstract 5022: Keratin15 (Krt15) + are radio resistant and tumor-initiating cells in the mouse small intestine Cancer Research · 2017
    26. The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate Trends in cell biology · 2018 · 33 citations
    27. Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science · 2010 · 1201 citations
    28. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    29. Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures Plastic and Reconstructive Surgery · 2013 · 39 citations
    30. The therapeutic promise of apoptosis Science · 2019 · 9 citations