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    Glossary Intestinal Stem Cells

    specialized cells in the gut that regenerate intestinal lining

    Intestinal Stem Cells (ISCs) are specialized cells located in the lining of the intestines that have the ability to self-renew and differentiate into various types of cells that make up the intestinal epithelium. These cells are crucial for maintaining the integrity and function of the gut by continuously replenishing the intestinal lining, which is constantly being worn down by digestive processes.

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    1. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments Nature Reviews Molecular Cell Biology · 2015 · 137 citations
    2. Metabolic Teamwork in the Stem Cell Niche Cell metabolism · 2017 · 14 citations
    3. Stem cell niche: from concept to reality Pigment Cell & Melanoma Research · 2012 · 1 citations
    4. Compartmentalized organization: a common and required feature of stem cell niches? Development · 2010 · 63 citations
    5. Dormancy in the stem cell niche Stem Cell Research & Therapy · 2012 · 29 citations
    6. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    7. Stem Cells in the Wild: Understanding the World of Stem Cells through Intravital Imaging Cell Stem Cell · 2014 · 17 citations
    8. Stem Cells in the Body 2017
    9. A family business: stem cell progeny join the niche to regulate homeostasis Nature Reviews Molecular Cell Biology · 2012 · 254 citations
    10. Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer Nature Reviews Genetics · 2018 · 124 citations
    11. A matter of life and death: self‐renewal in stem cells EMBO Reports · 2012 · 150 citations
    12. Ferreting out stem cells from their niches Nature Cell Biology · 2011 · 80 citations
    13. Tissue homeostasis Elsevier eBooks · 2008 · 2 citations
    14. Stem cell identification-<i>in vivo</i> lineage analysis versus <i>in vitro</i> isolation and clonal expansion The Journal of Pathology · 2012 · 17 citations
    15. Hardwiring Stem Cell Communication through Tissue Structure Cell · 2016 · 82 citations
    16. The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells edoc (University of Basel) · 2013
    17. Paneth Cells in Intestinal Homeostasis and Tissue Injury PLoS ONE · 2012 · 146 citations
    18. Modulating the stem cell niche for tissue regeneration Nature Biotechnology · 2014 · 480 citations
    19. Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair Stem Cells · 2013 · 50 citations
    20. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration Developmental Cell · 2021 · 25 citations
    21. The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015 · 66 citations
    22. Regulation of melanocyte stem cell behavior by the niche microenvironment Pigment Cell & Melanoma Research · 2018 · 24 citations
    23. Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages Experimental Cell Research · 2014 · 14 citations
    24. Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration <i>in vivo</i> The EMBO Journal · 2019 · 44 citations
    25. The stem cell niche The Journal of Pathology · 2008 · 209 citations
    26. NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor The EMBO Journal · 2019 · 91 citations
    27. Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair Stem Cell Reviews and Reports · 2016 · 24 citations
    28. Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche Stem Cell Reports · 2024 · 3 citations
    29. The Stem Cell Niche in Regenerative Medicine Cell stem cell · 2012 · 238 citations
    30. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013 · 6 citations