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    Glossary Interfollicular Stem Cells

    cells in skin between hair follicles aiding epidermis repair

    Interfollicular stem cells are a type of stem cell found in the skin, specifically in the areas between hair follicles. These cells play a crucial role in the regeneration and repair of the skin's outer layer, the epidermis, by continuously producing new skin cells to replace those that are shed or damaged.

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    1. Toxicological Responses in Keratinocyte Interfollicular Stem Cells 2018
    2. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    3. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    4. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations
    5. Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration Cell Cycle · 2015 · 47 citations
    6. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    7. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    8. Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide Journal of Investigative Dermatology · 2007 · 2 citations
    9. A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004 · 61 citations
    10. Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties Journal of Investigative Dermatology · 2025
    11. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling 2012 · 16 citations
    12. 25 Years of Epidermal Stem Cell Research Journal of Investigative Dermatology · 2012 · 55 citations
    13. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    14. 1337 Single cell transcriptome profiling of human interfollicular epidermis reveals robust heterogeneity and divergent differentiation lineages Journal of Investigative Dermatology · 2018
    15. The Progress of Epidermal Stem Cell Research 2010
    16. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    17. 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor Journal of Investigative Dermatology · 2022
    18. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage Journal of Cell Science · 1996 · 441 citations
    19. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    20. CD4 expression controls epidermal stem cell balance Scientific Reports · 2025 · 1 citations
    21. Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis Nature communications · 2022 · 7 citations
    22. Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy 2007 · 23 citations
    23. Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis Stem cell reviews and reports · 2022 · 7 citations
    24. Establishment and characterization of a canine keratinocyte organoid culture system Veterinary Dermatology · 2018 · 34 citations
    25. Abstract 5216: Impact of Stat3 deletion or activation on keratinocyte stem/progenitor cells Cancer Research · 2012
    26. Life before and beyond blistering: The role of collagen XVII in epidermal physiology Experimental Dermatology · 2018 · 63 citations
    27. Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids Stem cell reports · 2022 · 14 citations
    28. Fondation René Touraine Experimental Dermatology · 2013
    29. Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis Stem Cell Research & Therapy · 2015 · 14 citations
    30. Specific In Vivo Ablation of Lrig1-Positive Follicular Progenitor Cells Results in Sebaceous Gland Loss in Mice International Journal of Molecular Sciences · 2026