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    Glossary Interfollicular Epidermal Stem Cells

    specialized skin cells that regenerate and repair the epidermis

    Interfollicular Epidermal Stem Cells are specialized cells found in the outer layer of the skin, specifically between hair follicles. These cells play a crucial role in skin regeneration and repair by continuously producing new skin cells to replace those that are shed or damaged.

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    1. Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells. PubMed · 2005 · 25 citations
    2. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations
    3. Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration Cell Cycle · 2015 · 47 citations
    4. Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments Histochemistry and Cell Biology · 2010 · 28 citations
    5. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    6. 1337 Single cell transcriptome profiling of human interfollicular epidermis reveals robust heterogeneity and divergent differentiation lineages Journal of Investigative Dermatology · 2018
    7. Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide Journal of Investigative Dermatology · 2007 · 2 citations
    8. 1323 The effects of 3-OH of kaempferol on interfollicular epidermal stem cell fate Journal of Investigative Dermatology · 2018
    9. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    10. Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis Journal of Investigative Dermatology · 2004 · 10 citations
    11. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    12. The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis Anatomical Science International · 2016 · 14 citations
    13. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009 · 503 citations
    14. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution 2007 · 170 citations
    15. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017 · 105 citations
    16. Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation PLoS ONE · 2007 · 98 citations
    17. Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures Proceedings of the National Academy of Sciences · 2019 · 67 citations
    18. α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis Journal of Cell Science · 2003 · 45 citations
    19. CD4 expression controls epidermal stem cell balance Scientific Reports · 2025 · 1 citations
    20. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing Cell Reports · 2018 · 209 citations
    21. Single cell transcriptomics of human epidermis reveals basal stem cell transition states bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    22. Basal cells in the epidermis and epidermal differentiation Research Square (Research Square) · 2021
    23. Faculty Opinions recommendation of Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    24. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    25. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    26. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    27. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    28. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014 · 57 citations
    29. Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells Molecular biology of the cell · 2008 · 43 citations
    30. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations