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Glossary Intercellular Adhesion Molecule 1

protein aiding white blood cells in adhering to vessel walls

Intercellular Adhesion Molecule 1 (ICAM-1), also known as CD54, is a protein found on the surface of cells that plays a crucial role in the immune response. It helps white blood cells stick to and move through the walls of blood vessels to reach sites of infection or injury. This molecule is important in inflammation and can be involved in various diseases, including autoimmune disorders and cancer.

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research Intercellular Adhesion Molecule-1 and Hair Follicle Regression

29 citations , April 2000 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

This study found that ICAM-1 expression in murine skin is developmentally regulated and crucial for skin and hair follicle remodeling beyond its recognized role in immune responses.

Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

2 citations , February 2023 in “BMC women's health”

In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.

research Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma

13 citations , November 1995 in “European Archives of Oto-Rhino-Laryngology”

research Detection of Functionally Active Melanocortin Receptors and Evidence for an Immunoregulatory Activity of α-Melanocyte-Stimulating Hormone in Human Dermal Papilla Cells

60 citations , August 2005 in “Endocrinology”

This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.

research Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond

1 citations , January 2005 in “Experimental Dermatology”

This study found that α-MSH may suppress IFN-γ-driven upregulation of ICAM-1 in human dermal fibroblasts, suggesting potential roles for melanocortins in inflammatory skin disorders beyond collagen synthesis effects.

Analysis of Gene Expression in Isolated Single Hair Follicles Using Semiquantitative Reverse-Transcriptase Polymerase Chain Reaction

research Analysis of Gene Expression in Isolated Single Hair Follicles: An Approach Using Semiquantitative Reverse-Transcriptase—Polymerase Chain Reaction

May 1995 in “Journal of Investigative Dermatology”

Researchers developed a new way to measure gene activity in single hair follicles and found that a specific gene's activity changes with different amounts and times of treatment.

research Melanocortin receptors in fibroblastic cell types of the skin –in vitro and in vivo expression and functional relevance

1 citations , September 2004 in “Experimental Dermatology”

This study found that α-melanocyte-stimulating hormone may modulate inflammation in skin connective tissue by inhibiting proinflammatory effects in fibroblasts.

Periplaneta Americana Extract Promotes Hair Regrowth in Alopecia Areata Mice by Reducing Inflammation and Modulating Skin Microbiota

research Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota

August 2025 in “Frontiers in Pharmacology”

In this study, PA-011, a traditional Chinese medicine extract, was shown to improve hair growth in alopecia areata model mice by reducing skin inflammation and altering skin microbiota, indicating its potential therapeutic role for this condition.

research LOOSE ANAGEN SYNDROME AND LOOSE ANAGEN HAIR

25 citations , October 1996 in “Dermatologic Clinics”

This article discusses loose anagen syndrome, highlighting its characteristics, diagnostic methods, and spontaneous improvement over time, but provides no new clinical results.

research Intercellular junctions in normal epidermis

2 citations , September 2004 in “Experimental Dermatology”

This study found that desmosomal adhesion plays a crucial role in epithelial morphogenesis and cell positioning, equivalent in importance to that of adherens junctions.

research Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms

13 citations , February 2010 in “Stem Cell Reviews and Reports”

Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.

research Necl2 regulates epidermal adhesion and wound repair

35 citations , September 2009 in “Development”

This study found that overexpression of the intercellular adhesion protein Necl2 in hair follicle stem cells was associated with reduced cell proliferation and delayed wound healing in both cultured cells and transgenic mice.

research The Function and Structure of the Skin

4 citations , November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

This study found that the Foxn1(-/-) nude phenotype significantly influences epithelial progeny in skin, with notable changes in stem cell niches not achievable in other models.

research The Combination of Natural Compounds Escin–Bromelain–Ginkgo Biloba–Sage Miltiorrhiza (EBGS) Reduces Platelet Adhesion to TNFα-Activated Vascular Endothelium through FAK Signaling

4 citations , August 2024 in “International Journal of Molecular Sciences”

This study found that a combination of natural compounds (escin, bromelain, ginkgo biloba, and sage miltiorrhiza) reduced platelet adhesion to activated endothelium in laboratory settings by inhibiting adhesion molecule transcription and reducing pro-inflammatory cytokines, potentially preventing initial steps of the coagulation cascade.

research Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation

8 citations , February 2014 in “Stem cells translational medicine”

This study found that human mesenchymal stem cells overexpressing JAM-A improved hair follicle structure and hair formation in mice by reducing abnormalities such as curved and zigzagged follicles.

research Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells

8 citations , February 2017 in “International journal of molecular sciences”

This study found that the natural extract e-CAF promotes the proliferation and migration of human hair dermal papilla cells in vitro, suggesting potential benefits for skin regeneration and tissue repair.

research Dysfunction of keratinocyte adhesion

2 citations , September 2004 in “Experimental Dermatology”

This review discusses how dysfunction in keratinocyte adhesion affects skin integrity and conditions like alopecia and keratoderma, highlighting the roles of intercellular junctions, and reports no new clinical results.

research Current Genetics in Hair Diseases

1 citations , February 2013 in “InTech eBooks”

Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.

research Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes

99 citations , January 2004 in “Journal of Biological Chemistry”

This study found that methylprednisolone can block IgG-induced keratinocyte detachment in an animal model of pemphigus vulgaris, potentially by increasing the synthesis and modifying adhesion molecules.

research Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

28 citations , September 2020 in “International Journal of Molecular Sciences”

This study concluded that leucocyte-rich PRP has a continuous stimulatory effect on human fibroblast cells, enhancing their proliferation, migration, and impacting gene expression of the extracellular matrix and adhesion molecules.

research Cell fate decisions: emerging roles for metabolic signals and cell morphology

100 citations , November 2017 in “EMBO Reports”

This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.

research Role of regeneration in tissue repairing and therapies

6 citations , January 2015 in “Journal of regenerative medicine & tissue engineering”

This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.

research Targeting integrin pathways: mechanisms and advances in therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

This review examines integrins as pharmacological targets, discussing current integrin-based therapies and emphasizing the need to understand integrin mechanisms for successful drug development, without reporting new clinical results.

research More than One Gene Involved in Monilethrix: Intracellular but also Extracellular Players

35 citations , May 2006 in “Journal of Investigative Dermatology”

Monilethrix involves multiple genes affecting hair structure, including DSG4 mutations.

Atherogenesis: Estrogen Induction of Polysialylated NCAM Blocks Monocyte Capture by Vascular Endothelial Cells

research Atherogenesis: Estrogen Induction of Polysialylated nCAM (PSA-nCAM) Blocks Monocyte Capture by Vascular Endothelial Cells

January 2019 in “ISGE series”

This study found that estradiol and other sex steroids reduced the capture of monocytes by human endothelial cells in vitro, potentially inhibiting the formation of atherosclerosis by promoting nCAM polysialylation, which interferes with leukocyte tethering to the vascular endothelium.

research Molecular histology in skin appendage morphogenesis

57 citations , August 1997 in “Microscopy Research and Technique”

This review discusses novel molecular techniques in skin appendage research and summarizes the distribution of key molecules, but it reports no new experimental results.

research Role of Extracellular Vesicles as Mediators of Cell Communication and Novel Biomarkers in Sepsis

2 citations , September 2025 in “Journal of Clinical Medicine”

This review highlights the promise of small extracellular vesicles (sEVs) as biomarkers for sepsis, emphasizing their potential to improve early detection and guide therapeutic decisions by reflecting the immune status and pathogen presence in patients.

research Eph/ephrin signaling in epidermal differentiation and disease

42 citations , October 2011 in “Seminars in Cell & Developmental Biology”

This review explores the role of Eph receptors and ephrins in skin cell processes, discussing their potential for therapeutic targeting in dermatological disorders, but it presents no new research findings.

An Investigation of Keratin 15 Function by Small Interfering RNA Technology

research An Investigation of Keratin 15 Function by Small Interfering Ribonucleic Acid Technology

January 2012 in “Durham e-Theses (Durham University)”

This study found that knock-down of keratin 15 in various cell lines affected cell spreading, morphology, migration, differentiation, and proliferation, suggesting its role in maintaining the stem cell nature of keratinocytes.