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30 / 1000+ results research Molecular Predictors of Ritlecitinib Efficacy in Alopecia Areata: Role of JAK3-Dependent Inflammation and Follicular Integrity
This study examined molecular predictors of ritlecitinib efficacy in treating alopecia areata, highlighting the role of JAK3-dependent inflammation and follicular integrity as important factors in understanding disease mechanisms and potential therapeutic effectiveness.
research Recent advances in understanding and managing male infertility
This review discusses recent research on male infertility causes and treatments, emphasizing the need for further understanding of idiopathic sperm abnormalities and molecular factors to improve patient outcomes; it reports no new clinical results.
research Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss
This study presents a new model for androgenetic alopecia progression, explaining diffuse hair loss in women through 3D reconstructions of the arrector pili muscle and its relationship with the hair follicle stem cell niche.
research Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerating Healing
This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.
research Hair Medulla and its variations in Doshaja Prakruti – An observational study
This study observed distinct variations in hair medulla patterns among people with different Ayurvedic Prakruti types, linking stronger hair integrity to Kapha-dominant types and weaker, fragmented medullae to Vata and Pitta-dominant types, potentially aiding in Dosha-specific hair care and assessment.
research Comparative in vivo assessment of hair-growth efficacy using nanostructured lipid carriers individually loaded with lavender oil or tea seed oil
In this study, researchers reported that topical nanostructured lipid carriers containing tea seed or lavender oil significantly enhanced hair regrowth in female Wistar albino rats over 30 days compared to placebo, with increased hair length and follicular density observed.
research Components of skin boosters: A therapeutic role in dermatologic conditions
This review highlights that various components of "skin boosters," such as exosomes and hyaluronic acid, may have potential applications beyond aesthetics, acting as adjunct therapies for improving skin integrity and promoting tissue regeneration, though more research is needed to support their use as primary treatments.
research Biomimetics Through Bioconjugation of 16- Methylheptadecanoic Acid to Damaged Hair for Hair Barrier Recovery
This study found that bioconjugating 16-methylheptadecanoic acid (16-MHA) to damaged hair can mimic the protective properties of 18-methyleicosanoic acid (18-MEA), restoring the hair's structural integrity and moisture homeostasis, even after washing.
research The Role of Interface Geometry and Appendages on the Mesoscale Mechanics of the Skin
This study developed finite element models to examine skin's biomechanical properties, finding that structural heterogeneities like Rete ridges and hair follicles create distinct stress and strain patterns that may influence mechanosensation and skin integrity.
research Stem cells tightly regulate dead cell clearance to maintain tissue fitness
This study found that stem cells can temporarily act as non-professional phagocytes during hair cycle regeneration by clearing apoptotic cells through a process requiring local lipids and retinoids for activation, providing insights into their dual role in maintaining tissue integrity.
research Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis
This study found that epidermal-specific deletion of integrin α3β1 significantly reduces papilloma formation in a skin carcinogenesis model by modulating HB stem cell behavior and CCN2 expression.
research Development and Evaluation of a Novel Fish-Derived Protein Peptide Conditioner Formulated with Pneumatophorus japonicus Heads Peptides
This study found that a hair conditioner using peptides from Pneumatophorus japonicus heads improved damaged hair's structure, gloss, and smoothness more effectively than a commercial wheat protein conditioner by increasing amino acid content and interacting with hair keratin.
research Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
This study found that Par3 plays a crucial role in maintaining epidermal homeostasis by regulating Rho/actomyosin contractility and ensuring mitotic accuracy, with potential implications for other self-renewing epithelia.
research Human retinal secretome: A cross-link between mesenchymal and retinal cells
This review discusses the interaction between mesenchymal stem cell secretomes and retinal cell secretomes, suggesting their potential in experimental therapies to protect and regenerate retinal tissue.
research Niosomes as Efficient Nanocarriers for Targeted Drug Delivery
This research discusses advancements in niosomal drug delivery systems, highlighting their promising potential to improve targeted drug delivery due to their ability to encapsulate various drug types efficiently, offering advantages over traditional liposome systems in terms of chemical stability and therapeutic efficacy.
research V Congress of the Portuguese Society of Cosmetological Sciences - Proceedings
This article reviews EU cosmetic product claim regulations and highlights increased harmonization and enforcement while reporting no new results.
research Immunomodulatory Effects of Platelet-Rich Plasma (PRP) on Neuroinflammation: Insights from B92 Glial Cells Stimulated with Heat-Killed Escherichia coli
This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.
research PNKP is required for maintaining the integrity of progenitor cell populations in adult mice
This study observed that disrupting the Pnkp gene in adult mice resulted in a premature aging-like phenotype, suggesting PNKP's vital role in maintaining normal growth and survival of certain progenitor cell populations.
research Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V
This study identified a new heterozygous missense variant in CST6 associated with autosomal dominant keratosis follicularis spinulosa decalvans in an Austrian family, affecting epidermal differentiation and hair formation.
research Integrin signalling regulates YAP/TAZ to control skin homeostasis
In this study, researchers found that YAP and TAZ, when localized in the nucleus of basal layer cells, are crucial for skin regeneration and hair growth, with their loss leading to slower cell proliferation, hair loss, and impaired wound healing in mice.
research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis
This study identified key genes and signaling pathways involved in the growth phases of Pashmina goat hair follicles, highlighting the role of several gene families and transcription factors in fiber quality and growth regulation.
research Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin
This study used single-cell techniques and lineage tracing to reveal that integrin α6 expression in neural crest cells can differentiate them into Schwann cells, melanocytes, and fibroblasts in skin, identifying integrin α6 as a potential marker for these derivatives.
research Knockout of integrin β1 in induced pluripotent stem cells accelerates skin-wound healing by promoting cell migration in extracellular matrix
This study found that knocking out the integrin β1 subunit in induced pluripotent stem cells enhanced their migration and improved their wound-healing effects in a mouse model.
research DESENVOLVIMENTO BIOTECNOLÓGICO DE SÉRUM REJUVENESCEDOR ANTIOXIDANTE CONTENDO ATIVO LIPÍDICO ORIUNDO DA RANA CATESBEIANA SHAW
This study introduced an innovative antioxidant serum for skin care, using a lipid active from Rana catesbeiana Shaw, and validated its rejuvenating potential through physical-chemical and microbiological tests that ensured its antioxidant effectiveness, microbiological safety, and formulation stability.
research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats
This study found that transcriptome profiling of cashmere goat skin revealed key genes and pathways involved in hair follicle initiation, differentiation, and maturation, which are critical for improving fleece production.
research Solubility of minoxidil in binary mixture of ethanol + water at various temperatures
This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.
research Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82
This study identified KRT82 as a significant Alopecia Areata risk gene, finding that rare damaging variants are linked to elevated immune cell infiltration around hair follicles in affected individuals.
research The genetic basis of dermatophytosis skin infection susceptibility
In this study, researchers conducted a large genome-wide association meta-analysis and found 30 significant genetic loci linked to the risk of dermatophytosis, shedding light on the roles of keratin biology, skin barrier defects, immune dysfunction, and obesity in the disease.
research Reversing Time with Peptides: Mechanisms, Classifications, and Innovations in Anti-aging Interventions
This review found that anti-aging peptides show promise in cosmeceuticals due to their targeted actions to rejuvenate skin, but challenges like peptide stability, penetration, and limited clinical data limit their current effectiveness.