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    Glossary Integrin

    Integrins are transmembrane proteins that play a crucial role in cell adhesion, signaling, and communication within the extracellular matrix. In the context of hair biology, integrins are involved in the regulation of hair follicle development, cycling, and the interaction between hair follicle cells and their surrounding environment. Their relevance to hair loss lies in their influence on the health and function of hair follicles; disruptions in integrin signaling can contribute to conditions such as alopecia and other forms of hair thinning. Key distinguishing characteristics of integrins include their ability to bind to specific ligands and their role in mediating cellular responses to mechanical and biochemical signals.

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    1. Integrin signalling regulates YAP/TAZ to control skin homeostasis Development · 2016 · 266 citations
    2. Targeting integrin pathways: mechanisms and advances in therapy Signal Transduction and Targeted Therapy · 2023 · 54 citations
    3. α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis Journal of Cell Science · 2003 · 45 citations
    4. The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites Journal of Cell Science · 2015 · 28 citations
    5. Targeted inactivation of integrin-linked kinase in hair follicle stem cells reveals an important modulatory role in skin repair after injury Molecular Biology of the Cell · 2011 · 22 citations
    6. β1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis Journal of Investigative Dermatology · 2013 · 17 citations
    7. Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells International Journal of Molecular Sciences · 2015 · 17 citations
    8. miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades Journal of Advanced Research · 2024 · 15 citations
    9. Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin Journal of Investigative Dermatology · 2019 · 14 citations
    10. Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration American Journal Of Pathology · 2020 · 10 citations
    11. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations
    12. The Yin and Yang of Integrin Function in Re-Epithelialization During Wound Healing Advances in Wound Care · 2013 · 8 citations
    13. Promotion of mouse ameloblast proliferation by Lgr5 mediated integrin signaling Journal of Cellular Biochemistry · 2013 · 7 citations
    14. RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells Frontiers in Bioengineering and Biotechnology · 2024 · 6 citations
    15. Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin Frontiers in Cell and Developmental Biology · 2023 · 5 citations
    16. Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis Life science alliance · 2020 · 5 citations
    17. Blocking <i>α</i>1‐integrin reverts the adhesive phenotype of adult fibroblasts towards a foetal‐like migratory phenotype Experimental Dermatology · 2016 · 4 citations
    18. Knockout of integrin β1 in induced pluripotent stem cells accelerates skin-wound healing by promoting cell migration in extracellular matrix Stem Cell Research & Therapy · 2022 · 3 citations
    19. Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Graying and Changes in Integrin Expression 2023 · 1 citations
    20. Keratin Biomaterials Activate Schwann Cells via Integrin‐Mediated Signaling and Promote Regeneration of Large Peripheral Nerve Defects in a Rabbit Model The FASEB Journal · 2009
    21. Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling Frontiers in Medicine · 2025
    22. Data Sheet 1_Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling.pdf OPAL (Open@LaTrobe) (La Trobe University) · 2025
    23. 265 Loss of Langerhans cells in scar lesion of lichen planopilaris is caused by downregulation of integrin αvβ6 in the epidermal keratinocytes 2017
    24. Integrin-linked kinase inhibition via QLT0267 stops the epithelial outgrowth. OPAL (Open@LaTrobe) (La Trobe University) · 2015
    25. Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss Journal of Clinical Dermatology · 2008
    26. The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration 2010
    27. Integrando análise química e o saber popular: Tem cafeína no xampu bomba de café? Revista Iluminart · 2026
    28. β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny PLoS ONE · 2013 · 20 citations
    29. The microanatomy of the distal arrector pili: possible role for α1β1 and α5β1 integrins in mediating cell‐cell adhesion and anchorage to the extracellular matrix Journal of Cutaneous Pathology · 2000 · 15 citations
    30. Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism. Matrix Biology · 2024 · 8 citations