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GlossaryInsulin-like Growth Factor Binding Proteins

regulate insulin-like growth factors' activity and availability

Insulin-like Growth Factor Binding Proteins (IGFBPs) are a group of proteins that bind to insulin-like growth factors (IGFs), which are hormones involved in growth and development. By binding to IGFs, IGFBPs regulate their activity, availability, and interaction with IGF receptors, thereby playing a crucial role in cell growth, differentiation, and metabolism.

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iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

19 citations, December 2016 in “PLOS ONE”

Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.

research Tissue-Selective Regulation of Androgen-Responsive Genes

14 citations, May 2012 in “Endocrine Research”

The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.

research Transcriptome Profiling of Human Follicle Dermal Papilla Cells in Response to Porphyra-334 Treatment by RNA-Seq

7 citations, January 2021 in “Evidence-based complementary and alternative medicine”

Porphyra-334 may help reduce wrinkles and promote hair growth.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations, August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Serum Irisin: A Prognostic Marker for Severe Acne Vulgaris

8 citations, September 2018 in “Journal of Cosmetic Dermatology”

Lower irisin levels in the blood may indicate more severe acne.

research The Hedgehog-GLI1 Pathway Is Important for Fibroproliferative Properties in Keloids and as a Candidate Therapeutic Target

December 2023 in “Communications biology”

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

10 citations, December 2021 in “Frontiers in cell and developmental biology”

The research identified genes that explain why some sheep have curly wool and others have straight wool.

research Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep

19 citations, June 2020 in “Animals”

Poor maternal nutrition can lead to fewer wool follicles in Chinese Merino sheep.

research The Biology of Hair Diversity

47 citations, January 2013 in “International Journal of Cosmetic Science”

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

research Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

15 citations, May 2020 in “BMC complementary medicine and therapies”

Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.

research The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells

28 citations, December 2012 in “The American Journal of Cosmetic Surgery”

Proteins from stem cells improved hair growth in patients with hair loss.

research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

28 citations, August 2011 in “Journal of The American Academy of Dermatology”

Early hair loss may indicate prostate issues.

research Human Umbilical Cord Blood Mesenchymal Stem Cells Engineered to Overexpress Growth Factors Accelerate Outcomes in Hair Growth

21 citations, January 2018 in “The Korean Journal of Physiology and Pharmacology”

Modified stem cells from umbilical cord blood can make hair grow faster.

Prevalence of Polycystic Ovaries in Women with Self-Reported Symptoms of Oligomenorrhoea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study

research Prevalence of Polycystic Ovaries in Women with Self-Reported Symptoms of Oligomenorrhoea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study

77 citations, March 2004 in “Human Reproduction”

Women with irregular periods and/or excessive body hair are more likely to have polycystic ovaries, and this condition is linked to higher health risks.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations, January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

research Female Gonadal Function Before and After Treatment of Acromegaly

74 citations, July 2010 in “The Journal of Clinical Endocrinology & Metabolism”

Treatment of acromegaly can improve women's reproductive health issues caused by hormonal imbalances or tumors.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

33 citations, February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

research Hyperandrogenism and Polycystic Ovary Syndrome in Women with Type 1 Diabetes Mellitus

96 citations, February 2007 in “The Journal of Clinical Endocrinology & Metabolism”

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

3 citations, January 2017 in “Yonsei Medical Journal”

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

research Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

37 citations, June 2017 in “Journal of Investigative Dermatology”

Blocking a protein called CXXC5 with a specific peptide can stimulate hair regrowth and new hair growth in wounds.

research The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

19 citations, January 2017 in “Stem Cells International”

Adipose-derived stem cells show promise in treating skin conditions like vitiligo, alopecia, and nonhealing wounds.

research Use of Insulin-Sensitizing Agents in Patients With Polycystic Ovary Syndrome

32 citations, July 2001 in “Endocrine Practice”

Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations, January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Polycystic Ovary Syndrome and Infertility: An Update

26 citations, July 2021 in “International journal of adolescent medicine and health”

New treatments for PCOS are improving fertility and managing symptoms better.

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

19 citations, May 2020 in “Cells”

Substance from human umbilical cord blood cells promotes hair growth.

research Review on Polycystic Ovarian Syndrome (PCOS) in Case of Pregnancy

October 2023 in “International Journal For Multidisciplinary Research”

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

research Insulin Resistance and Polycystic Ovary Syndrome

November 2004 in “John Wiley & Sons, Ltd eBooks”

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.