Search
for

    Did you mean Inner Root Sheath?
    Glossary Inner Root Sheath

    layer of cells supporting and shaping the growing hair shaft

    The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    2. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle Journal of Investigative Dermatology · 2006 · 93 citations
    3. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    4. A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001 · 45 citations
    5. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    6. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans British Journal of Dermatology · 2001 · 38 citations
    7. Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study Journal of the American Academy of Dermatology · 2010 · 31 citations
    8. Investigation of the hair follicle inner root sheath in scarring and non‐scarring alopecia Journal of Cutaneous Pathology · 2007 · 28 citations
    9. Structural features of the α-type filaments of the inner root sheath cells of the guinea pig hair follicle Biochemistry · 1978 · 24 citations
    10. Functional analysis of keratin components in the mouse hair follicle inner root sheath British Journal of Dermatology · 2004 · 23 citations
    11. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis Experimental Dermatology · 2008 · 22 citations
    12. μ-Crystallin, Thyroid Hormone-binding Protein, is Expressed Abundantly in the Murine Inner Root Sheath Cells Journal of Investigative Dermatology · 2000 · 22 citations
    13. Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs Journal of Anatomy · 2004 · 20 citations
    14. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene 2012 · 17 citations
    15. Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution Journal of morphology · 2004 · 15 citations
    16. Synthesis of porcine pCLCA2 protein during late differentiation of keratinocytes of epidermis and hair follicle inner root sheath 2012 · 13 citations
    17. Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins Acta Histochemica · 2013 · 12 citations
    18. Pili Trianguli et Canaliculi Is a Defect of Inner Root Sheath Keratinization 2005 · 8 citations
    19. Fine structure of marsupial hairs, with emphasis on trichohyalin and the structure of the inner root sheath Journal of morphology · 2004 · 8 citations
    20. Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair Annals of anatomy · 2011 · 7 citations
    21. Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia The American Journal of Dermatopathology · 2018 · 6 citations
    22. Cytochemistry of Trichohyalin Granules: A Possible Role for Cornification of Inner Root Sheath Cell in the Hair Follicle The Journal of Dermatology · 1989 · 4 citations
    23. A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle Genes · 2021 · 2 citations
    24. Four murine monoclonal antibodies specific for the inner root sheath in the human hair follicle 1989 · 1 citations
    25. Hair-raising Mysteries of the Inner Root Sheath: Unearthing Treasures in Bald Spots 2025
    26. Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages Gene · 2024
    27. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    28. Keratinization of outer root sheath cells is prevented by contact with inner root sheath of rat hair follicles Archives of Dermatological Research · 2008 · 9 citations
    29. Some observations on the proteins of the inner root sheath cells of hair follicles Biochimica et Biophysica Acta · 1958 · 34 citations
    30. 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo Journal of Investigative Dermatology · 2024 · 1 citations