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    Glossary Inner Root Sheath

    layer of cells supporting and shaping the growing hair shaft

    The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

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    Research 30 of 1000+

    1. Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages Gene · 2024
    2. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    3. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle Journal of Investigative Dermatology · 2006 · 93 citations
    4. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    5. A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001 · 45 citations
    6. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    7. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans British Journal of Dermatology · 2001 · 38 citations
    8. Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study Journal of the American Academy of Dermatology · 2010 · 31 citations
    9. Investigation of the hair follicle inner root sheath in scarring and non‐scarring alopecia Journal of Cutaneous Pathology · 2007 · 28 citations
    10. Structural features of the α-type filaments of the inner root sheath cells of the guinea pig hair follicle Biochemistry · 1978 · 24 citations
    11. Functional analysis of keratin components in the mouse hair follicle inner root sheath British Journal of Dermatology · 2004 · 23 citations
    12. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis Experimental Dermatology · 2008 · 22 citations
    13. μ-Crystallin, Thyroid Hormone-binding Protein, is Expressed Abundantly in the Murine Inner Root Sheath Cells Journal of Investigative Dermatology · 2000 · 22 citations
    14. Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs Journal of Anatomy · 2004 · 20 citations
    15. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene 2012 · 17 citations
    16. Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution Journal of morphology · 2004 · 15 citations
    17. Synthesis of porcine pCLCA2 protein during late differentiation of keratinocytes of epidermis and hair follicle inner root sheath 2012 · 13 citations
    18. Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins Acta Histochemica · 2013 · 12 citations
    19. Pili Trianguli et Canaliculi Is a Defect of Inner Root Sheath Keratinization 2005 · 8 citations
    20. Fine structure of marsupial hairs, with emphasis on trichohyalin and the structure of the inner root sheath Journal of morphology · 2004 · 8 citations
    21. Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair Annals of anatomy · 2011 · 7 citations
    22. Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia The American Journal of Dermatopathology · 2018 · 6 citations
    23. Cytochemistry of Trichohyalin Granules: A Possible Role for Cornification of Inner Root Sheath Cell in the Hair Follicle The Journal of Dermatology · 1989 · 4 citations
    24. A KRT71 Loss-of-Function Variant Results in Inner Root Sheath Dysplasia and Recessive Congenital Hypotrichosis of Hereford Cattle Genes · 2021 · 2 citations
    25. Four murine monoclonal antibodies specific for the inner root sheath in the human hair follicle 1989 · 1 citations
    26. Hair-raising Mysteries of the Inner Root Sheath: Unearthing Treasures in Bald Spots 2025
    27. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    28. Isolation and properties of inner sheath cells of hair follicles Experimental Cell Research · 1964 · 26 citations
    29. Keratinization of outer root sheath cells is prevented by contact with inner root sheath of rat hair follicles Archives of Dermatological Research · 2008 · 9 citations
    30. 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo Journal of Investigative Dermatology · 2024 · 1 citations