Search
for

    Did you mean Inner Root Sheath?
    Glossary Inner Root Sheath

    layer of cells supporting and shaping the growing hair shaft

    The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Structural features of the α-type filaments of the inner root sheath cells of the guinea pig hair follicle Biochemistry · 1978 · 24 citations
    2. Cytochemistry of Trichohyalin Granules: A Possible Role for Cornification of Inner Root Sheath Cell in the Hair Follicle The Journal of Dermatology · 1989 · 4 citations
    3. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    4. Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle. PubMed · 1990 · 44 citations
    5. μ-Crystallin, Thyroid Hormone-binding Protein, is Expressed Abundantly in the Murine Inner Root Sheath Cells Journal of Investigative Dermatology · 2000 · 22 citations
    6. Keratinization of outer root sheath cells is prevented by contact with inner root sheath of rat hair follicles Archives of Dermatological Research · 2008 · 9 citations
    7. Some observations on the proteins of the inner root sheath cells of hair follicles Biochimica et Biophysica Acta · 1958 · 34 citations
    8. A novel monoclonal antibody to the outer root sheath cells Journal of Dermatological Science · 1994 · 3 citations
    9. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    10. Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study Journal of the American Academy of Dermatology · 2010 · 31 citations
    11. Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair Annals of anatomy · 2011 · 7 citations
    12. Hair-raising Mysteries of the Inner Root Sheath: Unearthing Treasures in Bald Spots 2025
    13. Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus 1997 · 38 citations
    14. Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins. 1986 · 356 citations
    15. Glycoconjugate expression of cells of human anagen hair follicles during keratinization The Anatomical Record · 1990 · 12 citations
    16. Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature Frontiers in cell and developmental biology · 2021 · 10 citations
    17. The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein 1993 · 2 citations
    18. LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis Scientific Reports · 2022 · 8 citations
    19. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000 · 31 citations
    20. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    21. Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel Annals of translational medicine · 2022 · 4 citations
    22. Cell kinetics of the human hair follicle Clinics in dermatology · 1988 · 1 citations
    23. Hair follicle regeneration from human pluripotent stem cells Journal of clinical & experimental dermatology research · 2017
    24. Wnt-10b promotes differentiation of skin epithelial cells in vitro Biochemical and Biophysical Research Communications · 2006 · 36 citations
    25. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    26. A STUDY OF THE DIFFERENTIATION PRODUCTS OF THE HAIR FOLLICLE CELLS WITH THE ELECTRON MICROSCOPE. PubMed · 1964 · 19 citations
    27. Acid phosphatase distribution in the wool follicle. III. Fate of organelles in keratinized cells Journal of ultrastructure research · 1976 · 6 citations
    28. 840 Early and late matrix progenitors form the terminally differentiated cell layers of the hair follicle Journal of Investigative Dermatology · 2017
    29. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle Genes & development · 2001 · 165 citations
    30. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells Development · 2013 · 74 citations