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    Glossary Inflammatory Mediators

    substances released to initiate and regulate inflammation

    Inflammatory mediators are substances released by immune cells and other tissues in response to injury or infection, which help to initiate and regulate the inflammatory response. These can include cytokines, prostaglandins, and histamines, among others, and they play crucial roles in signaling pathways that lead to symptoms like redness, swelling, and pain. Understanding these mediators is essential for developing treatments for conditions like alopecia, where inflammation can contribute to hair loss.

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    1. Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses Journal of Investigative Dermatology · 2018 · 26 citations
    2. Inflammatory perspectives of polycystic ovary syndrome: role of specific mediators and markers Middle East Fertility Society Journal · 2023 · 31 citations
    3. Cardamonin inhibits the expression of inflammatory mediators in TNF-α-stimulated human periodontal ligament cells Immunopharmacology and Immunotoxicology · 2024 · 3 citations
    4. 0041 Comparative multi-omics highlights inflammatory monocyte-derived dendritic cells as key mediators of UVB-induced photosensitivity Journal of Investigative Dermatology · 2025
    5. 878 Influence of bovine milk oligosaccharides on sebocyte lipid content and inflammatory mediators Journal of Investigative Dermatology · 2017
    6. Fatty acids and related lipid mediators in the regulation of cutaneous inflammation Biochemical Society Transactions · 2018 · 28 citations
    7. Phospholipase A<sub>2</sub> inhibition as potential therapy for inflammatory skin diseases Immunotherapy · 2013 · 13 citations
    8. Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-inflammatory and Endocrine Dysfunction: A Narrative Review Endocrine Connections · 2026
    9. 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways 2022
    10. Mediators of Inflammation in Polycystic Ovary Syndrome in Relation to Adiposity Mediators of Inflammation · 2010 · 102 citations
    11. 713 Fisetin promotes differentiation, inhibits proliferative and inflammatory responses in cultured human cells and alleviates psoriasiform dermatitis in mice Journal of Investigative Dermatology · 2017
    12. 415 Targeting inflammation and specialized pro-resolving mediators to reinforce barrier function and scalp homeostasis. Journal of Investigative Dermatology · 2022
    13. New developments in our understanding of acne pathogenesis and treatment Experimental dermatology · 2009 · 466 citations
    14. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015 · 359 citations
    15. Chapter 6 Fetal Skin Wound Healing Advances in Clinical Chemistry · 2009 · 89 citations
    16. ACNE Dermatologic Clinics · 1997 · 58 citations
    17. The skinny on slug Molecular Carcinogenesis · 2010 · 53 citations
    18. Cutaneous immunopathology of androgenetic alopecia. PubMed · 1991 · 10 citations
    19. Investigation of the Development of Hypersensitivity and Hyperalgesia After Repeated Application of Platelet-Rich Plasma in Rats: An Experimental Study Aesthetic Surgery Journal · 2019 · 7 citations
    20. Use of fluorescent light energy for the management of bacterial skin infection associated with canine calcinosis cutis lesions Veterinary record case reports · 2020 · 5 citations
    21. Microneedling: A means of collagen induction therapy Journal of dermatology & dermatologic surgery · 2021 · 4 citations
    22. Immunological and Metabolic Causes of Infertility in Polycystic Ovary Syndrome Biomedicines · 2023 · 3 citations
    23. Hair whitening in a patient with psoriasis on adalimumab reversed after switching to ixekizumab JAAD case reports · 2021 · 3 citations
    24. Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model Preprints.org · 2022 · 2 citations
    25. Abstract 18: Targeted epidermal ablation of EGFR causes local and systemic inflammation Cancer Research · 2010 · 2 citations
    26. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024 · 1 citations
    27. Anti-Allergic Effects of Fermented Red Ginseng Marc on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-like Mice Model Applied Sciences · 2022 · 1 citations
    28. Onabotulinum toxin A used to treat trichotillomania and trigeminal trophic syndrome 2024
    29. GPCRs as key regulators in wound healing Frontiers in Cell and Developmental Biology · 2026
    30. The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo Research Square (Research Square) · 2021