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Estrogen-progestin contraception lowers ovarian, endometrial, and colon cancer risk but may raise breast and cervical cancer risk, helps with menstrual and acne issues, and new methods are as effective as pills. Metformin helps overweight women with PCOS and insulin resistance, and dopamine agonists treat prolactinomas.

Hair restoration can effectively treat hair loss.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The method can effectively extract biomedical information without needing expert annotation, performing better than previous models.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Humans lost body hair relatively recently in evolution.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Clobetasol propionate ointment can help some people with total hair loss regrow hair.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.