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    Glossary Histamine

    chemical causing allergy symptoms and regulating gut functions

    Histamine is a chemical produced by the immune system that plays a crucial role in allergic reactions and regulating physiological functions in the gut. When released, it causes symptoms like itching, swelling, and redness by increasing the permeability of blood vessels, allowing immune cells to access affected tissues more easily.

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    1. New approaches to the physiology of histamine. Physiological Reviews · 1968 · 358 citations
    2. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid British Journal of Dermatology · 2015 · 5 citations
    3. Study on Histamine Related Enzyme Activities during Murine Hair Cycle. EXPERIMENTAL ANIMALS · 1997 · 4 citations
    4. Influence of glucocorticoids on a time-of-day-dependent variation in intradermal reactivity to histamine in dogs The Veterinary Journal · 2016 · 1 citations
    5. Application of histamine receptors H2R, H3R and H4R, but not H1R, in dermatology International Journal of Dermatology and Venereology · 2014
    6. Effects of botulinum toxin type A on histamine-induced itch and vasomotor responses in human skin Toxicon · 2008
    7. Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules PloS one · 2016 · 22 citations
    8. Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells Journal of Dermatological Science · 2012 · 2 citations
    9. 898 Homeostatic activation of epidermal HSD11b1 affects skin innervation and non-histaminergic itch 2017
    10. Advances in histamine-mediated allergy management: Expanding perspectives on cetirizine’s therapeutic, safety, and toxicological implications Archives of Clinical Toxicology · 2025
    11. Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata Journal of Dermatological Science · 2010 · 35 citations
    12. TRPV3 as a Therapeutic Target for Itch Journal of Investigative Dermatology · 2012 · 88 citations
    13. A subpopulation of itch‐sensing neurons marked by Ret and somatostatin expression EMBO reports · 2016 · 70 citations
    14. The itchy scalp - scratching for an explanation Experimental dermatology · 2011 · 61 citations
    15. Scalp Pruritus: Review of the Pathogenesis, Diagnosis, and Management BioMed Research International · 2019 · 37 citations
    16. Antianaphylactic activity of alcoholic extract of<i>Eclipta alba</i> Journal of Young Pharmacists · 2009 · 19 citations
    17. FPRL1 Receptor Agonist Peptides Prevent Etoposide-Induced Alopecia in Neonatal Rats Journal of Investigative Dermatology · 2004 · 8 citations
    18. Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation BioMed Research International · 2019 · 4 citations
    19. Alopecia areata in atopic dermatitis: coincidence or regularity? Russian Medical Inquiry · 2022 · 3 citations
    20. Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons Science advances · 2023 · 2 citations
    21. Diffuse Hair Loss Following Multiple Honeybee Stings Dermatology · 1997 · 1 citations
    22. Functional medical approach and management for long COVID 2023 · 1 citations
    23. 442 Deciphering the role of keloid fibroblasts in itch Journal of Investigative Dermatology · 2025
    24. [Effect of auricular point electrostimulation on pruritus induced by dextran in the mice]. PubMed · 2025
    25. 176 Characterising Neurotransmitter Signalling in Human Skin and Hair Follicles Journal of Investigative Dermatology · 2024
    26. Effect of Nymphaea caerulea Flower Extract on Improving Scalp Diseases Korean Journal of Pharmacognosy · 2024
    27. 338 Scalp disorders when the head is covered most of the day: An upcycled pink berry extract to the rescue Journal of Investigative Dermatology · 2021
    28. Signalling Underlying Wound Healing Encyclopedia of Life Sciences · 2019
    29. A SUBPOPULATION OF ITCH RECEPTORS MARKED BY RET EXPRESSION Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2014
    30. Circulation, sensation, and hair growth: A reply Journal of The American Academy of Dermatology · 2022