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Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Proper diet management is crucial for phenylketonuria patients to avoid severe health issues.

Medications for PCOS don't seem to raise heart disease risk.

Identifying nonclassic congenital adrenal hyperplasia and carriers of CYP21 mutations is challenging, and genetic counseling is recommended due to their prevalence.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

A new gene mutation causes insulin resistance in a girl and her mother.

Hyperandrogenism increases heart disease risk in premenopausal women, but this risk is linked to obesity in postmenopausal women.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.

The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

The research found that anovulatory young women have higher androgen and hormone levels than those who ovulate, suggesting immature hormonal regulation rather than a specific condition.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

The normal human prostate does not significantly affect blood DHT levels.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.

Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

Two siblings with a genetic mutation had a form of rickets that doesn't respond to vitamin D.