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Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

Two siblings with a genetic mutation had a form of rickets that doesn't respond to vitamin D.

Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

Western diet may cause male pattern baldness; low glycemic diet with magnesium could help.

Diabetes often causes various skin problems and complications.

Isotretinoin is safe and effective for acne, with common side effects like dry lips; serious side effects are rare.

Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.

The Protein-Sparing Modified Fast is effective for rapid weight loss and maintaining it, but requires medical supervision and can have side effects.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Minoxidil treats high blood pressure and side effects can be managed.

Taking metformin with intense-pulsed-light therapy improves hair removal for people with PCOS.

Finasteride caused enlarged breast tissue in a 62-year-old man.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Certain Dibenzo derivatives may help treat prostate cancer.

Biotin supplements are unnecessary for most people but may help with certain conditions like biotin deficiency, brittle nails, and some hair loss.

Hormonal therapies are effective for managing hair and skin symptoms in women with PCOS.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.