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    Glossary Heat Shock Proteins

    help cells survive stress by stabilizing and refolding damaged proteins

    Heat Shock Proteins (HSPs) are a group of proteins that are produced by cells in response to stressful conditions, such as elevated temperatures, toxins, or other environmental stressors. They function as molecular chaperones, helping to stabilize and refold damaged proteins, thereby protecting cells from stress-induced damage. HSPs are crucial for maintaining cellular function and integrity, and their role is significant in various biological processes, including protein homeostasis and the stress response.

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    1. Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2. PubMed · 1992 · 31 citations
    2. The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature International Journal of Molecular Sciences · 2023 · 3 citations
    3. Single-cell analysis of basal cell carcinoma reveals heat shock proteins promote tumor growth in response to WNT5A-mediated inflammatory signals bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    4. Elevated serum heat shock protein-70 and interleukin-15: prognostic biomarkers correlating with clinical severity and diagnostic efficacy in active alopecia areata Journal of the Egyptian Womenʼs Dermatologic Society · 2026
    5. Correlation of immunological variables of interleukin-17 and heat shock protein-70 in ethnic women with polycystic ovary syndrome South Eastern European Journal of Public Health · 2024
    6. Expression of the heat shock protein-27 in the adult human scalp skin and hair follicle: Hair cycle–dependent changes Journal of the American Academy of Dermatology · 2006 · 24 citations
    7. Heat shock protein 25 plays multiple roles during mouse skin development Cell Stress and Chaperones · 2005 · 14 citations
    8. Correlation of Immunological Variables of Interleukin-17 and Heat Shock Protein-70 In Ethnic Women with Polycystic Ovary Syndrome South Eastern European Journal of Public Health · 2024
    9. Up-regulation of androgen receptor by heat shock protein 27 and miR-1 induces pathogenesis of androgenic alopecia. PubMed · 2022
    10. Risks of Protein Conditioner Application under the Impact of Heat and/or Gamma Irradiation in Albino Rats 2021
    11. Dietary supplementation with L-glutamine enhances immunity and reduces heat stress in Hanwoo steers under heat stress conditions 2022 · 3 citations
    12. Vitamin A regulates dermal papilla cell proliferation and apoptosis under heat stress via IGF1 and Wnt10b signaling Ecotoxicology and environmental safety · 2023 · 2 citations
    13. Structural Characterization and Ligand Specific Protein Interactions of Androgen Receptor The Knowledge Bank (The Ohio State University) · 2008
    14. Susan Lee Lindquist (1949–2016)—pioneer in the study of cellular protein folding and disease EMBO journal · 2016 · 2 citations
    15. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    16. Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009 · 49 citations
    17. From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet? Molecular and Cellular Endocrinology · 2017 · 17 citations
    18. Identification of androgen-regulated genes in SV40-transformed human hair dermal papilla cells Journal of dermatological science · 2003 · 12 citations
    19. Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going Frontiers in Surgery · 2022 · 3 citations
    20. Skin Gamma Delta T Cell Gene Expression Highlights Stress Response in Alopecia Areata 2258104 The Journal of Immunology · 2026
    21. Medicinal Plants as Reservoirs of Endophytic Bacterial Genes Regulating Stress Tolerance: A Metagenomic Study on Eclipta prostrata (L.) L. Israel Journal of Plant Sciences · 2026
    22. 877 Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes 2023
    23. Topical olive oil with downregulation of stress factors protects mice skin from precarious 3600 MHz electromagnetic radiation. The Egyptian Journal of Histology · 2020
    24. Cutaneous Response to Injury and Wound Healing 2016
    25. 13. Wound Healing & Hair Journal of Cutaneous Medicine and Surgery · 2003
    26. Modulation der Hitzesensitivität im Prostatakarzinom in vitro: Der Einfluss der Androgenachse 2022
    27. Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata Scientific Reports · 2018 · 19 citations
    28. Therapeutic effect of mesenchymal stem cells on histopathological, immunohistochemical, and molecular analysis in second-grade burn model Stem Cell Research & Therapy · 2021 · 10 citations
    29. Molecular functional analyses revealed essential roles of HSP90 and lamin A/C in growth, migration, and self-aggregation of dermal papilla cells Cell death discovery · 2018 · 10 citations
    30. Effects of dihydrotestosterone on rat dermal papilla cells in vitro European Journal of Pharmacology · 2015 · 19 citations