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    Did you mean Heat Shock Protein 27?
    Glossary Heat Shock Protein 27

    small protein that helps protect cells from stress

    Heat Shock Protein 27 (HSP27), also known as HSPB1, is a small protein that helps protect cells from stress by preventing the aggregation of damaged proteins and assisting in their proper folding. It plays a crucial role in cellular responses to heat shock, oxidative stress, and other environmental stressors, and is also involved in processes like apoptosis (programmed cell death) and inflammation.

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    1. Expression of the heat shock protein-27 in the adult human scalp skin and hair follicle: Hair cycle–dependent changes Journal of the American Academy of Dermatology · 2006 · 24 citations
    2. Up-regulation of androgen receptor by heat shock protein 27 and miR-1 induces pathogenesis of androgenic alopecia. PubMed · 2022
    3. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    4. Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009 · 49 citations
    5. Effects of dihydrotestosterone on rat dermal papilla cells in vitro European Journal of Pharmacology · 2015 · 19 citations
    6. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022
    7. Susan Lee Lindquist (1949–2016)—pioneer in the study of cellular protein folding and disease EMBO journal · 2016 · 2 citations
    8. Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2. PubMed · 1992 · 31 citations
    9. The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature International Journal of Molecular Sciences · 2023 · 3 citations
    10. Elevated serum heat shock protein-70 and interleukin-15: prognostic biomarkers correlating with clinical severity and diagnostic efficacy in active alopecia areata Journal of the Egyptian Womenʼs Dermatologic Society · 2026
    11. Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata Scientific Reports · 2018 · 19 citations
    12. Dietary supplementation with L-glutamine enhances immunity and reduces heat stress in Hanwoo steers under heat stress conditions 2022 · 3 citations
    13. From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet? Molecular and Cellular Endocrinology · 2017 · 17 citations
    14. Vitamin A regulates dermal papilla cell proliferation and apoptosis under heat stress via IGF1 and Wnt10b signaling Ecotoxicology and environmental safety · 2023 · 2 citations
    15. Molecular functional analyses revealed essential roles of HSP90 and lamin A/C in growth, migration, and self-aggregation of dermal papilla cells Cell death discovery · 2018 · 10 citations
    16. Therapeutic effect of mesenchymal stem cells on histopathological, immunohistochemical, and molecular analysis in second-grade burn model Stem Cell Research & Therapy · 2021 · 10 citations
    17. Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going Frontiers in Surgery · 2022 · 3 citations
    18. Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides Advances in Redox Research · 2024
    19. Heat Preconditioning of Nanofat Does Not Improve Its Vascularization Properties Cells · 2025 · 2 citations
    20. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    21. Transcriptomic inspection revealed a possible pathway regulating the formation of the high-quality brush hair in Chinese Haimen goat ( <i>Capra hircus</i> ) Royal Society Open Science · 2018 · 11 citations
    22. Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone Morphogenetic Protein-2/Smad-Dependent Runx2 Pathway Evidence-based Complementary and Alternative Medicine · 2013 · 18 citations
    23. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion 2011 · 30 citations
    24. Exosomes mediate sensory hair cell protection in the inner ear Journal of Clinical Investigation · 2020 · 49 citations
    25. Prevention of chemotherapy-induced alopecia in rodent models Cell stress & chaperones · 2008 · 27 citations
    26. Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization 2024
    27. Beyond Hormones: A Systematic Review of the Risk of Cardiovascular Diseases in Polycystic Ovary Syndrome Cureus · 2024 · 10 citations
    28. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019 · 38 citations
    29. Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model Cell Stress and Chaperones · 2010 · 18 citations
    30. Ex Vivo Assessment of Heat and Humidity Effects on Human Skin and Potential Protection by Kombucha Tea Extract Cosmetics · 2026