October 2025 in “Nephrology Dialysis Transplantation” In this case report, a young woman experienced acute kidney injury linked to the use of a hair straightening product containing glyoxylic acid, suggesting dermal absorption may lead to calcium oxalate nephropathy; this highlights the need for regulatory review and public health intervention.
150 citations
,
July 2001 in “Clinics in dermatology” This article discusses hair care practices and hair cosmetics in managing alopecia but reports no new clinical findings; it emphasizes the importance of scalp health and good patient-physician communication.
November 2025 in “Contact Dermatitis” This study reported a case of acute kidney injury and toxic contact dermatitis in a 25-year-old woman following exposure to a glyoxylic acid-containing hair straightening product, highlighting glyoxylic acid's potential role in cutaneous and renal complications and underscoring the need for stronger regulation and awareness.
August 2025 in “Clinical Toxicology” This study suggests an association between glyoxylic acid-containing hair-straightening treatments and acute kidney injury in young women, with urine calcium oxalate crystals observed in some cases, indicating potential nephrotoxicity. Early treatment with thiamine and pyridoxine may mitigate the severity of kidney damage.
73 citations
,
October 2013 in “International Journal of Cosmetic Science” This review examines the chemical composition and potential health risks of hair straighteners, but it reports no new findings and emphasizes the importance of understanding hair fibre structure for safe use.
September 2023 in “Journal of the American Academy of Dermatology” This meta-analysis found a significant positive association between frontal fibrosing alopecia and both sunscreen and moisturizer use, with the moisturizer association significant only in males.
193 citations
,
January 2015 in “International journal of trichology” This review examines hair cosmetics, including shampoos and conditioners, for their formulations and effects, but reports no new clinical findings; it emphasizes the importance of dermatologist knowledge in treating diverse hair conditions.
54 citations
,
September 2000 in “Archives of dermatology” In this study, 95% of respondents reported severe hair breakage or loss after using the Rio Hair Naturalizer System, with many experiencing significant and lasting hair loss.
2 citations
,
January 2019 in “Applied clinical research, clinical trials and regulatory affairs” This review discusses the regulations and clinical safety aspects of hair care cosmetics, highlighting the FDA's recommendation to evaluate these products for allergic reactions, avoid contamination, and include antimicrobial agents to ensure consumer safety, with ongoing monitoring through consumer feedback.
1 citations
,
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” This chapter reviews the anatomy and structure of hair, discusses hair damage and analyses, and explores methods for processing hair changes, but presents no new research findings.
53 citations
,
July 2016 in “Cosmetics” This study reviews the biology and cosmetic treatment of hair, emphasizing future advancements in safer, more effective procedures to meet consumer needs for hair care.
43 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article reviews innovations in hair cosmetics, focusing on esthetic procedures and products in the Indian market, and reports no new experimental findings.
2 citations
,
May 2002 in “Clinics in Dermatology” This study found that androgenic alopecia is present in 22% of women with polycystic ovary syndrome and is associated with other clinical signs of hyperandrogenism, but not with increased biochemical hyperandrogenemia or metabolic dysfunction.
13 citations
,
November 2012 in “International Journal of Dermatology” This study of African-American women found that those perceiving greater hair breakage showed lower break stress and higher premature failure rates, linked to grooming practices and hair curvature.
December 2000 in “Kirk-Othmer Encyclopedia of Chemical Technology” This paper reviews various aspects of hair care products, including formulations, regulations, categories, and safety, without reporting new clinical findings.
55 citations
,
March 2007 in “Journal of cosmetic dermatology” This review discusses the historical development of hair straightening products for Afro-ethnic hair and reports no new research findings.
4 citations
,
January 2021 in “Skin appendage disorders” This review discusses hair straightening techniques, products, and safety risks, providing guidance for dermatologists to advise patients effectively; it reports no new clinical results.
July 2024 in “Minerva Digital Library (Universidad EAN)” In this study, the researchers addressed the development of a new hair treatment prototype as an innovative alternative to current chemical hair straightening products, highlighting possible health risks and environmental concerns associated with conventional treatments. Results are not provided in the abstract.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers formulated and evaluated an herbal hair smoothing cream containing natural ingredients like aloe vera and coconut oil, reporting significant improvements in hair smoothness, softness, shine, and manageability without irritation, suggesting it as a safer alternative to traditional hair straightening products.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that a formulated herbal hair smoothing cream using ingredients like aloe vera and coconut oil improved hair texture, such as smoothness and shine, without irritation, offering a safer alternative to conventional products.
3 citations
,
June 2008 in “Springer eBooks” Hair care products clean, protect, style, color, and change hair structure.
May 2026 in “Jurnal Pendidikan Kimia Fisika dan Biologi” This study found that rebonding hair straightening treatments visibly damage the hair cuticle, causing surface erosion and cracks, as shown through Scanning Electron Microscopy analysis.
September 2024 in “Cutis” Sunscreen use may increase the risk of frontal fibrosing alopecia.
6 citations
,
October 2006 in “International Journal of Dermatology” This article discusses central trichoptilosis with onycholysis but provides no new clinical results.
1 citations
,
October 2021 in “Indian Journal of Plastic Surgery/Indian journal of plastic surgery” This study highlights that improving medical professionals' knowledge of hair cosmetics can enhance patient adherence to alopecia treatments and reduce health risks from incorrect use of hair products.
13 citations
,
March 2017 in “Skin Research and Technology” In this study, formaldehyde hair straighteners significantly damaged curly hair by reducing break stress and break extension, while glyoxylic acid had a milder effect; both treatments increased shear modulus and decreased water sorption.
10 citations
,
January 1994 This study discusses that permanent hair straightening can be achieved at neutral or acidic pH conditions, with varying effects on cystine and lanthionine levels, by inducing supercontraction of the hair fiber.
1 citations
,
January 2025 in “JAAD reviews.” This review from JAAD highlights disparities in the effectiveness of hair preservation techniques for Black women undergoing chemotherapy, noting that current methods like scalp cooling often underperform due to structural differences in Black hair, and recommends tailored strategies such as adjusting hair preparation before treatment.
98 citations
,
June 2008 in “Human mutation” This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.
11 citations
,
June 2018 in “Annales de dermatologie et de vénéréologie” This narrative review discusses adverse reactions associated with hair care products, specifically irritation dermatitis and allergic contact eczema, and suggests the need for attention to common allergens like PPD, GMTG, and ammonium persulphate.