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    Glossary Hair Matrix Cell Proliferation

    process where hair follicle cells rapidly divide for growth

    Hair Matrix Cell Proliferation refers to the process by which cells in the hair matrix, located at the base of the hair follicle, rapidly divide and multiply. This cell division is crucial for hair growth, as these new cells push older cells upward, eventually forming the hair shaft that emerges from the scalp. For professionals, understanding this process is key to addressing hair growth disorders and developing treatments for conditions like alopecia.

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    1. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011 · 173 citations
    2. Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling International Journal of Molecular Sciences · 2019 · 23 citations
    3. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix European Journal of Cell Biology · 2017 · 30 citations
    4. Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects Biomedical Reports · 2022
    5. miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020 · 18 citations
    6. Differences in Hair Follicle Dermal Papilla Volume are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999 · 231 citations
    7. IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles Journal of Investigative Dermatology · 2023 · 9 citations
    8. “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women” Journal of Cosmetic Dermatology · 2019 · 3 citations
    9. Exogenous IGF-1 promotes hair growth by stimulating cell proliferation and down regulating TGF-β1 in C57BL/6 mice in vivo Growth Hormone & IGF Research · 2014 · 53 citations
    10. ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation BioMed Research International · 2020 · 2 citations
    11. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008 · 115 citations
    12. The Krüppel-like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation Journal of Biological Chemistry · 2003 · 88 citations
    13. 621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge Journal of Investigative Dermatology · 2019
    14. Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath 2024
    15. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    16. Basonuclin as a cell marker in the formation and cycling of the murine hair follicle Differentiation · 1998 · 27 citations
    17. Basonuclin as a cell marker in the formation and cycling of the murine hair follicle Differentiation · 1998
    18. Influence Of Extracellular Matrix On The Proliferation And Adhesion Properties Of Stem Cells Derived From Different Sources 2017 · 1 citations
    19. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth Pflügers Archiv - European Journal of Physiology · 2022
    20. 503 A new chemosensory control of human hair growth: Olfactory receptor OR10J1 stimulation promotes scalp hair follicle growth and progenitor cell generation ex vivo Journal of Investigative Dermatology · 2024
    21. The effects of extra cellular matrix and growth factors on dermal papilla cell proliferation Journal of dermatological science · 1994
    22. β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model Fitoterapia · 2017 · 14 citations
    23. Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix International Journal of Molecular Medicine · 2014 · 12 citations
    24. Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture British Journal of Dermatology · 1998 · 30 citations
    25. Organotypic Cocultures as Models to Study Cell-Cell and Cell-Matrix Interactions of Human Hair Follicle Cells Skin Pharmacology and Physiology · 1994 · 18 citations
    26. Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth Theranostics · 2020 · 46 citations
    27. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997 · 38 citations
    28. Vitamins and their derivatives synergistically promote hair shaft elongation ex vivo via PlGF/VEGFR-1 signalling activation Journal of dermatological science · 2022 · 1 citations
    29. PD-L1 vNAR promotes hair growth by modulating hair shaft elongation through activating the leptin-STAT3 signaling Cell Communication and Signaling · 2026
    30. Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines Journal of Applied Biomedicine · 2023