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    Glossary Hair Growth Factors

    naturally occurring proteins that stimulate hair follicle growth

    Hair Growth Factors are naturally occurring proteins or compounds that stimulate hair follicles to enter the growth phase, promoting hair development and reducing hair loss. These factors, such as keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF), play crucial roles in cellular signaling pathways that regulate the hair growth cycle, making them essential in both clinical treatments for alopecia and cosmetic hair care products.

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    1. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    2. Local Injection of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) Alters Cyclic Growth of Murine Hair Follicles Journal of Investigative Dermatology · 1998 · 109 citations
    3. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. PubMed · 1997 · 107 citations
    4. Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy Molecular Medicine Today · 1996 · 100 citations
    5. Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle 2003 · 94 citations
    6. GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE Dermatologic Clinics · 1996 · 90 citations
    7. Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation Journal of Dermatological Science · 2001 · 77 citations
    8. Fibroblast Growth Factors Stimulate Hair Growth through<i>β</i>-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015 · 64 citations
    9. In vivo promoted growth of mice hair follicles by the controlled release of growth factors Biomaterials · 2003 · 60 citations
    10. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    11. Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells Journal of Biochemistry and Molecular Biology · 2013 · 56 citations
    12. Hair Growth Induction: Roles of Growth Factors Annals of the New York Academy of Sciences · 1991 · 44 citations
    13. Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats Gene · 2015 · 42 citations
    14. The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth? Dermatology Online Journal · 2009 · 39 citations
    15. A role of placental growth factor in hair growth Journal of dermatological science · 2014 · 31 citations
    16. Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles International Journal of Molecular Medicine · 2011 · 28 citations
    17. Enhancing hair growth in male androgenetic alopecia by a combination of fractional CO2 laser therapy and hair growth factors Lasers in Medical Science · 2017 · 26 citations
    18. Narrow-band red LED light promotes mouse hair growth through paracrine growth factors from dermal papilla Journal of Dermatological Science · 2011 · 23 citations
    19. Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth Clinical, cosmetic and investigational dermatology · 2016 · 19 citations
    20. Intradermal injections of a hair growth factor formulation for enhancement of human hair regrowth – safety and efficacy evaluation in a first-in-man pilot clinical study Journal of Cosmetic and Laser Therapy · 2018 · 17 citations
    21. Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed 2021 · 17 citations
    22. Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades Biochemical and Biophysical Research Communications · 2016 · 14 citations
    23. Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro British Journal of Dermatology · 1987 · 9 citations
    24. Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 8 citations
    25. Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in an<i>in vitro</i>organ culture system International Journal of Dermatology · 2007 · 7 citations
    26. <i>Pinus thunbergii</i> bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice Molecular Medicine Reports · 2022 · 5 citations
    27. The potential role of fibroblast‐derived multi‐peptide factors in activation of growth factors and β‐Catenin in hair follicle cells Journal of Cosmetic Dermatology · 2022 · 4 citations
    28. Evaluation of efficacy of QR 678 and QR678 neo hair growth factor formulation for the treatment of female pattern alopecia in patients with PCOS—A prospective study Journal of Cosmetic Dermatology · 2020 · 4 citations
    29. More is not always better in hair growth factors. epidermal growth factor: hair growth factor involved in alopecia areata pathogenesis International Journal of Trichology · 2020 · 4 citations
    30. Epidermal growth factor promotes mesenchymal stem cell-mediated wound healing and hair follicle regeneration. PubMed · 2017 · 4 citations