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    Glossary Perifollicular Vascularization

    Perifollicular vascularization refers to the network of blood vessels surrounding hair follicles, which plays a crucial role in supplying nutrients and oxygen necessary for hair growth and maintenance. This vascularization is significant in the context of hair loss, as inadequate blood flow can lead to weakened hair follicles and contribute to conditions such as androgenetic alopecia. Key distinguishing characteristics include the density and health of the blood vessels, which can be influenced by factors such as age, hormonal changes, and overall scalp health. Enhanced perifollicular vascularization is often associated with improved hair growth and recovery from hair loss.

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    1. 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss Journal of Investigative Dermatology · 2021
    2. Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid 2014
    3. Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells Experimental Dermatology · 2015 · 35 citations
    4. Vascular endothelial cells: Targets for studying the activity of hair follicle cell-produced VEGF Cell Biology and Toxicology · 1996 · 9 citations
    5. Effects of the biomimetic peptide Sh-Polypeptide 9 (CG-VEGF) on cocultures of human hair follicle dermal papilla cells and microvascular endothelial cells Experimental Dermatology · 2015 · 7 citations
    6. Perifollicular vascularization: Cocultures and tricultures approaches to study the cross-talk between microvascular endothelial cells, follicle papilla cells and keratinocytes Vascular Pharmacology · 2015
    7. Control of hair growth and follicle size by VEGF-mediated angiogenesis Journal of Clinical Investigation · 2001 · 520 citations
    8. Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin Cancer Research · 2005 · 76 citations
    9. Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase Journal of Investigative Dermatology · 2003 · 52 citations
    10. The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model PLoS ONE · 2016 · 16 citations
    11. Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation The American Journal of Dermatopathology · 2016 · 8 citations
    12. Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling Frontiers in Medicine · 2025
    13. Data Sheet 1_Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling.pdf OPAL (Open@LaTrobe) (La Trobe University) · 2025
    14. Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus) PLoS ONE · 2013 · 81 citations
    15. Tissue engineering of human hair follicles using a biomimetic developmental approach Nature Communications · 2018 · 184 citations
    16. From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency Stem Cells · 2010 · 135 citations
    17. Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute Stem cell research & therapy · 2014 · 45 citations
    18. Clinically applicable transplantation procedure of dermal papilla cells for hair follicle regeneration Journal of Tissue Engineering and Regenerative Medicine · 2011 · 15 citations
    19. The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath Journal of Clinical Medicine · 2021 · 8 citations
    20. 3D multicellular micropatterning biomaterials for hair regeneration and vascularization Materials horizons · 2023 · 3 citations
    21. Silk fibroin hydrogel with recombinant silk fibroin/NT3 protein enhances wound healing by promoting Type III collagen synthesis and hair follicle regeneration in skin injury Materials Today Bio · 2025
    22. Gas-propelled anti-hair follicle aging microneedle patch for the treatment of androgenetic alopecia Journal of Controlled Release · 2025
    23. Regeneration of Human Hair Follicles by 3-D Bioprinting 2021
    24. Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis Journal of Controlled Release · 2022 · 12 citations
    25. The effect and mechanism of Yangxue Shengfa Capsules on hair growth in mice Xiandai yaowu yu linchuang · 2010
    26. Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential Current Issues in Molecular Biology · 2025
    27. Hair Regrowth in Alopecia Areata Patients: Insights from a Case Study Using Mesenchymal Stem Cell Conditioned Media 2024
    28. Peppermint Oil Promotes Hair Growth without Toxic Signs Toxicological Research · 2014 · 30 citations
    29. Angiogenin is expressed in human dermal papilla cells and stimulates hair growth Archives of dermatological research · 2008 · 20 citations
    30. GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells npj regenerative medicine · 2020 · 7 citations