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    Glossary Hair Follicle Damage

    injury to structures responsible for hair growth, causing hair loss

    Hair Follicle Damage, also known as Follicular Damage, refers to the harm or injury sustained by the hair follicles, which are the small structures in the skin responsible for hair growth. This damage can result from various factors such as physical trauma, chemical exposure, infections, or autoimmune conditions like alopecia areata. When hair follicles are damaged, it can lead to hair thinning, hair loss, or even permanent baldness if the follicles are severely affected.

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    1. A simple assay for the study of human hair follicle damage induced by ionizing irradiation Experimental dermatology · 2009 · 16 citations
    2. Transepidermal UV radiation of scalp skin <i>ex vivo</i> induces hair follicle damage that is alleviated by the topical treatment with caffeine International Journal of Cosmetic Science · 2019 · 31 citations
    3. 910 Transepidermal UV radiation of human scalp skin induces distinctive hair follicle damage, which is mitigated by topical caffeine treatment Journal of Investigative Dermatology · 2019
    4. Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage ˜The œFASEB journal · 2006 · 210 citations
    5. Exposure to non-ionizing electromagnetic fields emitted from mobile phones induced DNA damage in human ear canal hair follicle cells Electromagnetic biology and medicine · 2018 · 25 citations
    6. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022 · 20 citations
    7. PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair Frontiers in Cell and Developmental Biology · 2021 · 9 citations
    8. Eucommia ulmoides Bark Extract Attenuates Oxidative Damage and H2O2-Induced Hair Follicle Suppression in Cellular and Mouse Models Molecules · 2026
    9. An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging Aging · 2021 · 12 citations
    10. Nitrogen Mustard Induces DNA Damage and Structural Changes in Mouse Skin Hair Follicles The FASEB Journal · 2015
    11. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005 · 106 citations
    12. Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia International Journal of Molecular Medicine · 2012 · 28 citations
    13. Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-β Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by “Dystrophic Catagen” Promotion? Journal of Investigative Dermatology · 2008 · 18 citations
    14. The cause of primary and secondary damage to hair follicles on full thickness skin autografts Archives of Dermatological Research · 1974 · 2 citations
    15. 1360 Fate tracing of DNA-damaged hair follicle stem cells and their seno-differentiation clearance out of the niche 2023
    16. Vitamin A alleviates heat stress‐induced damage to hair follicle development in Rex rabbits Journal of the Science of Food and Agriculture · 2021 · 12 citations
    17. Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity Frontiers in Pharmacology · 2025 · 4 citations
    18. Topical application of cyclosporin A induces rapid-remodeling of damaged anagen hair follicles produced in cyclophosphamide administered mice Journal of Dermatological Science · 2001 · 24 citations
    19. Early stage alopecia areata is associated with inflammation in the upper dermis and damage to the hair follicle infundibulum Australasian Journal of Dermatology · 2013 · 22 citations
    20. Disruption of microtubules with low intensity ultrasound rescues hair follicle damage by paclitaxel in mouse models Nature Communications · 2026
    21. Mechanism-Based Strategies for Prevention of Taxane-Induced Hair Follicle Damage in Cancer Chemotherapy Cancers · 2026
    22. ESDR382 - Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge? 2022
    23. 1403 Melatonin protects K15+ human hair follicle stem cells against paclitaxel-induced damage ex vivo Journal of Investigative Dermatology · 2023
    24. 599 PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity 2019
    25. 382 Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge? 2022
    26. Melatonin protects K15+ human hair follicle stem cells and hair matrix keratinocytes against paclitaxel-induced damage ex vivo Journal of Investigative Dermatology · 2023 · 1 citations
    27. ISID1403 - Melatonin protects K15+ human hair follicle stem cells against paclitaxel-induced damage ex vivo 2023
    28. 17‐beta estradiol and prednisolone as potential stimulators of hair re‐growth in chemotherapy‐induced human hair follicle damage via ‘dystrophic catagen’ promotion? Experimental Dermatology · 2008
    29. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    30. Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation Stem cells · 2017 · 13 citations