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    Glossary Hair Cortex

    thickest hair layer, providing strength, elasticity, and color

    The hair cortex is the thickest layer of a hair strand, located between the outer cuticle and the inner medulla. It contains long keratin filaments that give hair its strength, elasticity, and color, as it houses the pigment granules responsible for hair color. This layer is crucial for the hair's structural integrity and overall health.

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    1. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers Development · 2000 · 109 citations
    2. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix Human Genetics · 1997 · 100 citations
    3. hKAP1.6 and hKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins are Expressed in the Hair Follicle Cortex 2002 · 24 citations
    4. Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex PloS one · 2011 · 21 citations
    5. Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge Experimental Dermatology · 2009 · 18 citations
    6. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016 · 14 citations
    7. The in vitro Assembly of Hair Follicle Keratins: Comparison of Cortex and Companion Layer Keratins Biological chemistry · 2002 · 13 citations
    8. Mutation detection of type II hair cortex keratin gene KRT86 in a Chinese Han family with congenital monilethrix Chinese Medical Journal · 2013 · 4 citations
    9. Characterization of the mechanical properties of the cortex region of human hair fibers by multiparametric Atomic Force Microscopy mapping Ultramicroscopy · 2024
    10. Thermal Induced Changes in Cuticle and Cortex to Chemically Treated Hair Biopolymers · 2025
    11. Cortexolone 17a-propionate: A new antiandrogen acting on hair dermal papilla cells for the treatment of androgenic alopecia Journal of The American Academy of Dermatology · 2014
    12. Context-dependent effect of sPLA2-IIA induced proliferation on murine hair follicle stem cells and human epithelial cancer EBioMedicine · 2019 · 13 citations
    13. A highly resistant structure between cuticle and cortex of human hair International Journal of Cosmetic Science · 2016 · 10 citations
    14. A highly resistant structure between the cuticle and the cortex of human hair. II. CARB, a penetration barrier International Journal of Cosmetic Science · 2018 · 6 citations
    15. Transmission electron microscopy staining methods for the cortex of human hair: a modified osmium method and comparison with other stains Journal of Microscopy · 2011 · 29 citations
    16. Mutation of the doublecortin gene in male patients with double cortex syndrome: Somatic mosaicism detected by hair root analysis Annals of Neurology · 2001 · 43 citations
    17. Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix Nature Genetics · 1997 · 175 citations
    18. Three-dimensional architecture of macrofibrils in the human scalp hair cortex Journal of Structural Biology · 2014 · 55 citations
    19. Nanoindentation of Hair Cortex and Medulla Regions 2019 · 3 citations
    20. Data from: Social hair plucking across affiliative and agonistic contexts, with health considerations, in captive rhesus macaques (<em>Macaca mulatta</em>) DRYAD · 2026
    21. A discrete transition zone between cuticle and cortex layers of a human hair fibre: changes observed in the presence of breast cancer ecancermedicalscience · 2017 · 1 citations
    22. 574 Murine sebaceous gland homeostasis requires intact cutaneous innervation in a hair cycle-dependent context 2019
    23. Mechanical properties characterization of human hair fibers cortex region by multiparametric Atomic Force Microscopy mapping Digital Library of Theses and Dissertations (Universidade de São Paulo) · 2021
    24. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000 · 88 citations
    25. Impact of ultraviolet radiation‐induced damage to hair fiber integrity: A multi‐technique physicochemical characterization of surface and cortex properties International Journal of Cosmetic Science · 2026
    26. Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology Molecules · 2025
    27. Zinc deficiency or genetic mutations?—A case report of hair heterochromia in the context of MC1R genetic mutations Australasian journal of dermatology (Print) · 2024
    28. Impact of acid (”progressive brush”) and alkaline straightening on the hair fiber: Differential effects on the cuticle and cortex properties International journal of trichology · 2022
    29. Micrografting in Extensive Quantities Please Note: In 1995 we began using Follicular Unit Transplantation for all hair restoration procedures performed at NHI. Minigrafting/micrografting techniques were discontinued at this time. This article should be read in that context. 1995
    30. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001 · 272 citations