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    Glossary Growth Factor Secretion

    cells release proteins that regulate growth and repair processes

    Growth Factor Secretion refers to the process by which cells release proteins known as growth factors into their surrounding environment. These growth factors play a crucial role in regulating various cellular processes, including cell growth, division, and differentiation, which are essential for tissue repair and regeneration. In the context of hair biology, growth factor secretion can influence hair follicle development and the hair growth cycle, potentially impacting conditions like alopecia.

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    1. 832 Variability in secretion of growth factors by platelets is intrinsic to alopecia patients undergoing platelet-rich plasma therapy Journal of Investigative Dermatology · 2020
    2. RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells Frontiers in Bioengineering and Biotechnology · 2024 · 6 citations
    3. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    4. Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: Effects of estrogen on vascular endothelial growth factor secretion Wound Repair and Regeneration · 2008 · 30 citations
    5. Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion Biomedical research · 2010 · 134 citations
    6. Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease Mediators of Inflammation · 2017 · 38 citations
    7. Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway Italian Journal of Medicine · 2023
    8. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase 2009 · 34 citations
    9. In vitro effects of baicalin on the growth of human hair follicles and secretion of vascular endothelial growth factor by human dermal papilla cells Chinese Journal of Dermatology · 2007 · 1 citations
    10. Impact of epidermal growth factor receptor and mitogen-activated kinase inhibition on hair follicles (HFs): partial HF immune privilege collapse and excessive interleukin-33 secretion British Journal of Dermatology · 2024 · 1 citations
    11. effects Of Low-level Laser Therapy (lllt) On Dermal Papilla Cell Proliferation And Insulin-like Growth Factor-1 (igf-1) Secretion From Balding Hair Follicles : #lb12 2014
    12. ACOS23O-002: The Use of Bone Marrow Mesenchymal Stem Cell Derived Cytokines and Growth Factors in The Management of Androgenetic Alopecia Journal of Asia Pacific Aesthetic Sciences · 2023
    13. Fibroblast‐derived growth factors and exosomes as cosmeceuticals Dermatological reviews · 2023
    14. THE EFFECT OF HAIR TONIC FROM SECRETOME MESENCHYMAL STEM CELL ON HAIR GROWTH IN HAIR LOSS CASES International Journal of Applied Pharmaceutics · 2026
    15. Stem cell secretome as a new booster for regenerative medicine Bioscience trends · 2019 · 54 citations
    16. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review Clinical, Cosmetic and Investigational Dermatology · 2021 · 26 citations
    17. 721 Efficacy of silybum marianum extract, manganese PCA and lespedeza capitata extract on hair growth and anchorage in human dermal papilla cells 2022
    18. Heterogeneity in amount of growth factors secreted by platelets in platelet‐rich plasma samples from alopecia patients Experimental dermatology · 2020 · 8 citations
    19. Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects Biomedical Reports · 2022
    20. Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery Pharmacology & Therapeutics · 2016 · 26 citations
    21. A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective International Journal of Molecular Sciences · 2022 · 8 citations
    22. Secretome of Mesenchymal Stromal Cells as a Possible Innovative Therapeutic Tool in Facial Nerve Injury Treatment BioMed Research International · 2023 · 2 citations
    23. Secretome of bovine umbilical vein endothelial cells promote wound healing regeneration on the second degree rat model burn injury Open veterinary journal · 2023
    24. Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells Journal of Tissue Engineering · 2026
    25. Limbal Mesenchymal Stem Cell Secretome as Potential Adjuvant Therapy for Ocular Alkali Injury 2022
    26. ROOT HAIR DEFECTIVE SIX‐LIKE4 (RSL4) promotes root hair elongation by transcriptionally regulating the expression of genes required for cell growth New phytologist · 2016 · 75 citations
    27. Boehmite enhances hair follicle growth via stimulation of dermal papilla cells by upregulating β‐catenin signalling Experimental Dermatology · 2019 · 12 citations
    28. ISX-9 Promotes KGF Secretion From MSCs to Alleviate ALI Through NGFR-ERK-TAU-β-Catenin Signaling Axis Stem Cells Translational Medicine · 2023 · 2 citations
    29. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    30. Adipose-derived Stem Cell Secretome and Its Potential Role in the Treatment of Androgenetic Alopecia Plastic and reconstructive surgery. Global open · 2021