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    Glossary Growth Differentiation Factor 8

    inhibits muscle growth by signaling muscles to stop growing

    Growth Differentiation Factor 8 (GDF-8), also known as Myostatin, is a protein that inhibits muscle growth. It plays a crucial role in regulating muscle mass by signaling muscles to stop growing, ensuring that muscle growth does not become excessive. This protein is of particular interest in medical research for its potential implications in treating muscle-wasting diseases and enhancing muscle growth in livestock.

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    1. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    2. LncRNA RP11-818O24.3 regulates proliferation and differentiation of hair follicle stem cells by targeting FGF2/PI3K/AKT pathway PLoS ONE · 2025 · 1 citations
    3. 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons Journal of Investigative Dermatology · 2024
    4. Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis Developmental dynamics · 1998 · 252 citations
    5. 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision Journal of Investigative Dermatology · 2017
    6. Expression ofWise in chick embryos Developmental Dynamics · 2007 · 6 citations
    7. A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective International Journal of Molecular Sciences · 2022 · 8 citations
    8. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    9. Cells Derived from Concentrated Growth Factor Exhibit a Multilineage Differentiation Capacity International Journal of Molecular Sciences · 2025 · 1 citations
    10. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations
    11. Enhancing hair growth in male androgenetic alopecia by a combination of fractional CO2 laser therapy and hair growth factors Lasers in Medical Science · 2017 · 26 citations
    12. Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration Stem Cells · 2015 · 19 citations
    13. Combination of media, biomaterials and extracellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons Acta Biomaterialia · 2012 · 25 citations
    14. 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line Journal of Investigative Dermatology · 2019
    15. Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat The Anatomical Record · 1983 · 72 citations
    16. 14. Wound Healing; Cutaneous Therapy; Hair Medical & surgical dermatology · 2008
    17. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    18. Making the head: Caspases in life and death Frontiers in Cell and Developmental Biology · 2023 · 7 citations
    19. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations
    20. Ultrastructural Localization and Quantification of Extracellular Calcium Binding Sites in Mouse Vibrissa and Human Scalp Follicles Skin Pharmacology and Physiology · 1993 · 1 citations
    21. Ferrous Ferric Chloride Stimulates the Skin Cell Function and Hair Growth in Mice Biological & pharmaceutical bulletin · 2009 · 7 citations
    22. Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells Foods · 2025
    23. The new regenerative and innovative strategies in hair loss 2021 · 3 citations
    24. Induction of cardiomyocyte‑like cells from hair follicle cells in mice International Journal of Molecular Medicine · 2019 · 1 citations
    25. Defining the Localization and Molecular Characteristic of Minor Salivary Gland Label-Retaining Cells Stem cells · 2014 · 18 citations
    26. Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. PubMed · 1996 · 36 citations
    27. 136 Physiological function of Krox20 (Egr2) in epithelial stem cells Journal of Investigative Dermatology · 2021
    28. Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells Pharmaceutics · 2021 · 28 citations
    29. BONE MORPHOGENETIC PROTEINS ARE CRITICAL FACTORS FOR HAIR FOLLICLE EPITHELIAL –MESENCHYMAL INTERACTIONS IN ANDROGENETIC ALOPECIA 2017
    30. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations