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    Did you mean Growth Differentiation Factor 8?
    Glossary Growth Differentiation Factor 8

    inhibits muscle growth by signaling muscles to stop growing

    Growth Differentiation Factor 8 (GDF-8), also known as Myostatin, is a protein that inhibits muscle growth. It plays a crucial role in regulating muscle mass by signaling muscles to stop growing, ensuring that muscle growth does not become excessive. This protein is of particular interest in medical research for its potential implications in treating muscle-wasting diseases and enhancing muscle growth in livestock.

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    1. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    2. Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation Journal of Embryology & Stem Cell Research · 2019 · 1 citations
    3. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    4. Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors Molecular Medicine Reports · 2013 · 24 citations
    5. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    6. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    7. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    8. Astragalus membranaceus and Cinnamomum cassia Stimulate the Hair Follicle Differentiation-Related Growth Factor by the Wnt/β-Catenin Signaling Pathway Current Issues in Molecular Biology · 2023
    9. Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart PLOS ONE · 2015 · 44 citations
    10. Cells Derived from Concentrated Growth Factor Exhibit a Multilineage Differentiation Capacity International Journal of Molecular Sciences · 2025 · 1 citations
    11. Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner Journal of Dermatological Science · 2016 · 10 citations
    12. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. PubMed · 1997 · 107 citations
    13. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    14. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors International Journal of Molecular Medicine · 2013 · 56 citations
    15. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations
    16. 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons Journal of Investigative Dermatology · 2024
    17. Enhancing hair growth in male androgenetic alopecia by a combination of fractional CO2 laser therapy and hair growth factors Lasers in Medical Science · 2017 · 26 citations
    18. Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation BMC Cancer · 2011 · 7 citations
    19. Synthesis of nerve growth factor mRNA in cultures of developing mouse whisker pad, a peripheral target tissue of sensory trigeminal neurons. The Journal of Cell Biology · 1993 · 5 citations
    20. Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes Archiv der Pharmazie · 2021 · 3 citations
    21. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    22. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor 2002 · 169 citations
    23. Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor Acta Dermato Venereologica · 2003 · 116 citations
    24. Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression The FASEB Journal · 2003 · 51 citations
    25. Mode of action of mouse epidermal growth factor on the wool follicles of Merino sheep: an ultrastructural study Australian Journal of Agricultural Research · 1989 · 9 citations
    26. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations
    27. The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth? Dermatology Online Journal · 2009 · 39 citations
    28. Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration Stem Cells · 2015 · 19 citations
    29. Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse Gene Expression Patterns · 2006 · 17 citations
    30. Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis Frontiers in Cell and Developmental Biology · 2021 · 4 citations