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Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Excess androgens may cause PCOS, not just be a symptom.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Some conditions mimic PCOS symptoms and need careful diagnosis to treat potentially serious health issues.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

The FRZB gene slows hair growth in rabbits.

Metformin can help prevent the side effects of glucocorticoid medications on metabolism.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.

Glucocorticoids can cause various health issues, but some treatments may help reduce these effects.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Certain medications can impact metabolic syndrome, with some improving conditions like high blood sugar and others having no effect.