Search

for
Search:

Did you mean Full-Thickness Skin Wounds?

Glossary Full-Thickness Skin Wounds

injuries penetrate through all skin layers, reaching deeper tissues

Full-Thickness Skin Wounds are injuries that extend through both the epidermis and dermis layers of the skin, reaching into the subcutaneous tissue or even deeper structures like muscle and bone. These wounds often require more complex medical interventions, such as surgical repair or skin grafting, due to the extensive tissue damage and potential for significant scarring.

Related Terms

Sort by

Research

30 / 1000+ results

Hyaluronic Acid-Based Hydrogels for Full-Thickness Wound Repairing and Skin Regeneration

research Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration

24 citations , September 2018 in “Journal of Materials Science: Materials in Medicine”

In this study using rabbits, HA2 hydrogels made from cross-linked hyaluronic acid and polysaccharide promoted wound healing better than other treatments, reducing inflammation and scar formation.

The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

research The Effect of Mesenchymal Stem Cells and Chitosan Gel on Full Thickness Skin Wound Healing in Albino Rats: Histological, Immunohistochemical and Fluorescent Study

23 citations , September 2015 in “PLOS ONE”

This study found that mesenchymal stem cells, especially when injected intradermally, significantly accelerated wound healing in rats compared to chitosan treatment.

research Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns

14 citations , January 2021 in “Scientific Reports”

This study found that "micro skin tissue columns" improved wound healing by enhancing re-epithelialization, collagen deposition, dermal remodeling, and reducing inflammation without causing long-term donor site morbidity.

research Treatment of Full-Thickness Skin Wounds with Blood-Derived CD34+ Precursor Cells Enhances Healing with Hair Follicle Regeneration

2 citations , May 2019 in “Advances in wound care”

In this study, nondermal-derived CD34+ cells from adult peripheral blood were found to enhance wound healing and contribute to hair follicle neogenesis and skin regeneration.

research Skin Epidermis and Adnexa Regrowth Induced by Treatment With Artificial Dermal Template After Full-Thickness Skin Wound

1 citations , January 2019 in “The International Journal of Lower Extremity Wounds”

This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.

research Chitosan Hydrogel Dressing Loaded with Adipose Mesenchymal Stem Cell-Derived Exosomes Promotes Skin Full-Thickness Wound Repair

1 citations , February 2024 in “ACS applied bio materials”

In a rat skin wound model, this study observed that a composite dressing using chitosan hydrogel and exosomes derived from adipose mesenchymal stem cells enhanced wound healing by promoting collagen deposition, angiogenesis, and regeneration of hair follicle structures.

research PLATELET-RICH PLASMA AS AN ADJUVANT IN FULL-THICKNESS SKIN WOUND HEALING IN RABBITS

April 2025 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ”

In this study, PRP significantly accelerated early wound healing in rabbits, with faster closure and improved tissue characteristics compared to controls, although both groups achieved near-complete healing by four weeks.

research Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration

March 2026 in “Gels”

In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.

Negative Pressure Wound Therapy Augmented Full-Thickness Free Skin Grafting in Cats: Outcome in 10 Grafts Transferred to Six Cats

research Negative pressure wound therapy augmented full-thickness free skin grafting in the cat: outcome in 10 grafts transferred to six cats

21 citations , February 2015 in “Journal of Feline Medicine and Surgery”

This study found that negative pressure wound therapy combined with skin grafting is a feasible method for treating soft tissue and skin defects in cats, achieving a high graft take rate and satisfactory outcomes.

The Repairing of Full-Thickness Skin Deficiency and Its Biological Mechanism Using Decellularized Human Amniotic Membrane as the Wound Dressing

research The repairing of full-thickness skin deficiency and its biological mechanism using decellularized human amniotic membrane as the wound dressing

47 citations , March 2017 in “Materials Science and Engineering: C”

In this study, decellularized human amniotic membrane was found to promote wound healing and reduce scar formation in rats with full-thickness skin defects, compared to traditional clinical treatments.

research In vivo expansion and regeneration of full‐thickness functional skin with an autologous homologous skin construct: Clinical proof of concept for chronic wound healing

38 citations , March 2019 in “International Wound Journal”

In this study, a new cell-tissue technology using a patient's own skin to create a full-thickness skin autograft successfully treated a chronic wound larger than 200 cm², achieving complete functional skin coverage within 12 weeks and maintaining results at a 6-month follow-up.

research The Use of Therapeutic Peptides in Combination with Full-Thickness Skin Columns to Improve Healing of Excisional Wounds

1 citations , August 2025 in “Bioengineering”

In this study, the combination of full-thickness skin column grafts and the TSN6 peptide improved wound healing quality in pigs by enhancing epidermal maturation compared to other treatments.

research Effect of Topical Linum usitatissimum on Full Thickness Excisional Skin Wounds

15 citations , September 2016 in “Trauma Monthly”

This study found that topical Linum usitatissimum gel significantly enhanced wound healing and tissue regeneration in rat models, with increased collagen synthesis and vascularization compared to controls.

Green Fabrication of Seedbed-Like Flammulina Velutipes Polysaccharides-Derived Scaffolds Accelerating Full-Thickness Skin Wound Healing Accompanied by Hair Follicle Regeneration

research Green fabrication of seedbed-like Flammulina velutipes polysaccharides–derived scaffolds accelerating full-thickness skin wound healing accompanied by hair follicle regeneration

14 citations , November 2020 in “International Journal of Biological Macromolecules”

This study found that Flammulina velutipes polysaccharides-derived scaffolds greatly enhanced wound healing and hair follicle regeneration in a rat model, particularly with the FPS/NaOH variant showing the best results.

research Silymarin enhanced fibroblast proliferation and tissue regeneration in full thickness skin wounds in rat models; a stereological study

11 citations , January 2013 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery”

This study found that applying silymarin gel topically on rat wounds improved fibroblast proliferation, collagen formation, and wound closure more than a gel-base alone or no treatment.

research Clinical and histological study of cold physical plasma jet in treatment of full thickness skin wounds of normal and diabetic dogs

September 2024 in “Journal of the Pakistan Medical Association”

This study found that helium non-equilibrium atmospheric pressure plasma jet therapy accelerated wound healing in both diabetic and non-diabetic dogs, promoting wound closure and histological improvements like epithelization and collagen deposition compared to untreated wounds.

Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

research Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

62 citations , March 2015 in “PLOS ONE”

In this study, microporous electrospun scaffolds pre-seeded with dermal fibroblasts accelerated wound healing and improved dermal matrix structure and hair follicle regeneration compared to acellular scaffolds in a rat model.

research Biological Macromolecule Hydrogel Based on Recombinant Type I Collagen/Chitosan Scaffold to Accelerate Full-Thickness Healing of Skin Wounds

12 citations , September 2023 in “Polymers”

This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.

research Chitosan/LiCl composite scaffolds promote skin regeneration in full-thickness loss

24 citations , January 2019 in “Science China Life Sciences”

Chitosan/LiCl composite scaffolds help heal deep skin wounds better.

research 745 Full thickness wound healing in the Lanyu pig

April 2016 in “Journal of Investigative Dermatology”

This study found that full thickness wounds in Lanyu pigs led to altered molecular expression and abnormal skin structure, without regenerating key epithelial cells thought to aid in skin regeneration.

research Extracellular matrix‐based combination scaffold for guided regeneration of large‐area full‐thickness rabbit burn wounds upon a single application

3 citations , November 2021 in “Journal of biomedical materials research. Part B, Applied biomaterials”

In a rabbit model, this study found that the AMFIBHA skin substitute promoted wound healing and regeneration of skin structures in large-area third-degree burn wounds, suggesting potential clinical use.

Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

research Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration after Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus

49 citations , March 2014 in “Journal of Investigative Dermatology”

This study demonstrated that combining AMD3100 with low-dose tacrolimus in a stem cell mobilization approach significantly reduced wound healing time and improved scar and hair follicle regeneration in full-thickness skin wounds.

research Two-Dimensional Biodegradable Black Phosphorus Nanosheets Promote Large Full-Thickness Wound Healing through In Situ Regeneration Therapy

57 citations , January 2024 in “ACS Nano”

This study found that black phosphorus nanosheets positively influence skin repair by enhancing angiogenesis, anti-inflammatory response, collagen deposition, and re-epithelialization in a rat model of skin wounds, potentially through activating the JAK-STAT-OAS signaling pathway.

research A double-layer scaffold composed of 3D bioprinted layer of granulocyte-colony stimulating factor and electrospun nanofibers of abietic acid for full thickness skin repair

July 2026 in “International Journal of Pharmaceutics X”

In this study, researchers developed a biopolymer-based dual-layer wound dressing that significantly improved healing outcomes in a 14-day rat model, reporting 94% wound closure by day 15 and enhanced tissue regeneration, swelling properties, and cell viability.

research De Novo Regeneration of Rete Ridges during Cetacean skin wound healing

March 2026

This study found that Fraser's Dolphin, a tight-skinned mammal, can regenerate complex skin architecture with minimal scarring after large full-thickness wounds, even in high-tension environments, offering insights into regenerative healing mechanisms typically obscured by fibrotic responses.

Sericin Hydrogels Promote Skin Wound Healing with Effective Regeneration of Hair Follicles and Sebaceous Glands After Complete Loss of Epidermis and Dermis

research Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis

84 citations , January 2018 in “Biomaterials Science”

Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.

research Novel PLCL nanofibrous/keratin hydrogel bilayer wound dressing for skin wound repair

6 citations , December 2022 in “Colloids and Surfaces B: Biointerfaces”

This study reported that a novel bilayer wound dressing made from PLCL nanofibers and keratin hydrogel, loaded with FGF-2, promoted skin healing and showed potential for use in skin tissue engineering.

ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

research ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

17 citations , June 2018 in “Frontiers in Physiology”

This study found that acellular dermal matrix scaffolds may facilitate full-thickness skin wound healing by promoting a pro-regenerative immune response through M2 macrophage polarization via the Lamtor1 pathway.

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

In this study, researchers achieved complete reepithelialization and hair growth on a burn-injured scalp using a tissue-engineered dermal template with early micrograft hair follicle implantation.

research Regeneration of rete ridges in Lanyu pig ( Sus scrofa ): Insights for human skin wound healing

15 citations , January 2019 in “Experimental Dermatology”

In this study, full-thickness wounding on Lanyu pigs led to scar formation and disrupted cell markers, while partial-thickness wounding allowed limited regeneration of rete ridges and papillary dermis.