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    Glossary Fibrosis

    formation of excess fibrous tissue, often causing scarring

    Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue as a reparative or reactive process. It often occurs as a result of chronic inflammation or injury, leading to scarring and potentially impairing the normal function of the affected area. For example, in the context of hair loss, fibrosis around hair follicles can prevent hair regrowth by disrupting the normal hair cycle.

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    1. Postmenopausal frontal fibrosing alopecia. Scarring alopecia in a pattern distribution Archives of Dermatology · 1994 · 332 citations
    2. Frontal fibrosing alopecia in postmenopausal women Journal of The American Academy of Dermatology · 2004 · 179 citations
    3. Fibrosing Alopecia in a Pattern Distribution Archives of dermatology · 2000 · 158 citations
    4. Post-menopausal frontal fibrosing alopecia Clinical and Experimental Dermatology · 2003 · 49 citations
    5. CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung Frontiers in Pharmacology · 2014 · 39 citations
    6. Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis Matrix Biology · 2005 · 38 citations
    7. Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis Frontiers in Immunology · 2018 · 37 citations
    8. WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling Experimental & Molecular Medicine · 2021 · 36 citations
    9. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages Annals of the Rheumatic Diseases · 2014 · 36 citations
    10. A Review of the Evidence for and against a Role for Mast Cells in Cutaneous Scarring and Fibrosis International Journal of Molecular Sciences · 2020 · 35 citations
    11. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    12. DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms Anais Brasileiros de Dermatologia · 2016 · 31 citations
    13. Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair Medicinal Research Reviews · 2019 · 30 citations
    14. Expression of Snail1 in the fibrotic dermis of postmenopausal frontal fibrosing alopecia: possible involvement of an epithelial-mesenchymal transition and a review of the Japanese patients British Journal of Dermatology · 2010 · 29 citations
    15. Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature Journal of Investigative Dermatology · 2017 · 26 citations
    16. Fibrosing alopecia in a pattern distribution Journal of the European Academy of Dermatology and Venereology · 2010 · 16 citations
    17. Diagnostic and Therapeutic Assessment of Frontal Fibrosing Alopecia 2007 · 16 citations
    18. Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis Science Translational Medicine · 2024 · 16 citations
    19. Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts Fundamental Research · 2021 · 12 citations
    20. Graft versus host disease presenting as fibrosing alopecia in a pattern distribution: A model for pathophysiological understanding of cicatricial pattern hair loss International Journal of Trichology · 2018 · 9 citations
    21. Pattern hair loss: Assessment of inflammation and fibrosis on histologic sections Journal of The American Academy of Dermatology · 2019 · 7 citations
    22. Clinicopathological characteristics and treatment outcomes of fibrosing alopecia in a pattern distribution: A retrospective cohort study Journal of the European Academy of Dermatology and Venereology · 2021 · 7 citations
    23. Tissue fibrosis associated depletion of lipid‐filled cells Experimental Dermatology · 2024 · 6 citations
    24. Reliability of Histopathology for the Early Recognition of Fibrosis in Traction Alopecia: Correlation with Clinical Severity Dermatopathology · 2019 · 5 citations
    25. Rapidly progressive diffuse fibrosing alopecia JAAD Case Reports · 2019 · 5 citations
    26. Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis The FASEB Journal · 2024 · 3 citations
    27. Divergent molecular signatures of regeneration and fibrosis during wound repair bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 3 citations
    28. Fibrosing alopecia in a pattern distribution in two brothers with pili multigemini 2015 · 3 citations
    29. Peculiar hypertrichosis in a patient affected by frontal fibrosing alopecia with pseudo "fringe sign" Giornale italiano di dermatologia e venereologia · 2020 · 2 citations
    30. Early Diagnosis and Prompt Treatment Improves Quality of Life in Patients with Frontal Fibrosing Alopecia Skin appendage disorders · 2019 · 2 citations