September 2025 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that applying a topical scalp essence with Centella asiatica extracellular vesicles and growth factors significantly improved scalp health and hair growth compared to a placebo after 56 days.
This study found that keratin-gelatin composite films effectively promoted early wound healing and full-thickness skin graft acceptance in dogs, outperforming bFGF-gelatin films.
December 2022 in “Plastic and Reconstructive Surgery” In this study, PRPF treatment was more effective than PRP alone in improving hair count and hair quality in androgenetic alopecia patients, with PRPF showing significant improvements in various hair growth parameters and having no statistical differences observed in the placebo group.
30 citations
,
March 2008 in “Wound Repair and Regeneration” This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.
1 citations
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December 2022 in “Current Issues in Molecular Biology” This study found that orally administered Annurca apple extract improved hair length, thickness, weight, and density in mice, while also increasing the expression of hair growth-related genes and proteins, suggesting potential as a natural treatment for hair loss.
June 2005 in “Key Engineering Materials” This study found that biodegradable hydrogels loaded with various growth factors significantly enhanced hair follicle growth and blood vessel formation in mice, demonstrating a positive effect on their hair growth cycle.
2 citations
,
January 2017 in “Journal of Cosmetics, Dermatological Sciences and Applications” In this study, TrichotechTM, a phytocomplex derived from essential oils, enhanced fibroblast proliferation, increased FGF-7 and FGF-10 gene expression, and boosted collagen content in cultured human fibroblasts.
90 citations
,
October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
21 citations
,
December 2023 in “Bioengineering & Translational Medicine” This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.
17 citations
,
November 2015 in “Oxidative Medicine and Cellular Longevity” This study suggests that FGF-9 treatment may improve cardiac function by reducing vascular apoptosis and enhancing angiogenesis in infarcted hearts of both nondiabetic and diabetic mice.
7 citations
,
April 2018 in “Molecular Medicine Reports” This study found that BeauTop, a supplement containing several traditional Chinese herbs, may promote hair growth in mice with alopecia, potentially by modulating EGF and FGF-7 levels.
November 2025 in “Biomacromolecules” This research found that four types of biocompatible nanochitin promoted hair growth in mice, with partially deacetylated and phosphoric acid hydrolyzed nanochitins showing the best results, while amphoteric nanochitin provided the most balanced overall effect.
August 2019 in “Research Square (Research Square)” This study explored how long non-coding RNA mediates the effects of FGF5 on the hair follicle development and villus growth of Liaoning cashmere goats.
115 citations
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February 2016 in “Nature Communications” The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.
October 2024 in “Current Issues in Molecular Biology” In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.
July 2023 in “International journal of trichology” In this randomized controlled trial, researchers found that Cellcurin therapy significantly increased hair density, terminal hair, and vellus hair counts in men and women with androgenetic alopecia, compared to minoxidil control, over 12 weeks.
March 2023 in “Journal of Applied Biomedicine” This study suggests that oleanolic acid may promote hair growth in mice with testosterone-induced androgenetic alopecia by activating the Wnt/β-catenin pathway and influencing various molecular levels.
In this randomized clinical trial, the use of Cellcurin serum for 12 weeks was associated with a significant increase in hair density and terminal hair thickness in individuals with androgenetic alopecia.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
6 citations
,
December 2023 in “Journal of Clinical Medicine” This review explores the potential link between psoriasis and metabolic syndrome, focusing on how disturbances in growth factors may connect these conditions and contribute to symptoms like keratinocyte proliferation and inflammation.
1 citations
,
January 2019 in “Journal of Embryology & Stem Cell Research” This review discusses mesenchymal stem cells' role in tissue regeneration and skin anti-aging, highlighting their migration to damaged sites and secretome effects, but reports no new clinical results.
This study found that platelet-derived extracellular vesicles from apheresis platelets may effectively activate dermal papilla cells and promote hair follicle growth in a mouse model of hair regeneration.
2 citations
,
June 2021 in “Research Square (Research Square)” This study identified a novel missense mutation in the FGF5 gene associated with the longhair phenotype in about 3% of Maine Coon cats, suggesting it may be a breed-specific variant.
1 citations
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January 1995 in “Lincoln University Research Archive (Lincoln University)” In this study, researchers found that wool growth regulation is likely achieved through endocrine growth factors, with various growth factors inhibiting fibre growth in vitro.
11 citations
,
July 2004 in “Journal of Investigative Dermatology” Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.
April 2023 in “Journal of Investigative Dermatology” HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.
1 citations
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July 2023 in “International Journal of Molecular Sciences” This study found that a hypoxic microenvironment enhanced the proliferation and pluripotency of adipose mesenchymal stem cells, promoting hair follicle formation and upregulating specific growth factors in Arbas Cashmere goats.
154 citations
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November 2017 in “Development” This review discusses the roles of fibroblast growth factors in tissue regeneration and repair across various organisms and tissues, but reports no new experimental findings, underscoring the need for further research.
January 2024 in “Skin appendage disorders” This article reviews existing research on the treatment of alopecia areata using growth factors and microneedling, reporting that these methods show promise in promoting hair growth without major adverse effects, but emphasizes the need for additional large-scale studies to confirm their efficacy and safety.
January 2023 in “Biomedicine & Pharmacotherapy” This study found that human embryonic stem cell-derived mesenchymal stem cells promote hair growth and enhance the transition from the telogen phase to the anagen phase in mice, especially under hypoxic conditions.