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    Glossary Fibroblast Activity

    production of collagen and extracellular matrix by connective tissue cells

    Fibroblast activity refers to the behavior and function of fibroblasts, which are specialized cells in connective tissue that produce collagen and other extracellular matrix components. These cells play a crucial role in wound healing, tissue repair, and maintaining the structural integrity of tissues. Enhanced fibroblast activity can lead to improved skin health and hair growth, while impaired activity may contribute to conditions like scarring or alopecia.

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    1. Catecholaminergic neurons boost fibroblast osteogenic activity in keloid Nature Communications · 2026
    2. Dopa oxidase activity in the hair, skin and ocular melanocytes is increased in the presence of stressed fibroblasts Experimental Dermatology · 2005 · 14 citations
    3. Extracellular vesicles derived from embryonic day 13 fetal mouse dermal fibroblasts exhibit potential antifibrotic activity Research Square · 2026
    4. 975 Antifibrogenic activities of novel vitamin D3 analogs are dependent on VDR expression in human fibroblasts Journal of Investigative Dermatology · 2019
    5. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    6. Antiaging Activity of Peptide Identified from Fermented <i>Trapa Japonica</i> Fruit Extract in Human Dermal Fibroblasts Evidence-based Complementary and Alternative Medicine · 2020 · 14 citations
    7. Structural Characterization and Wound Healing Activity of Sulfated Glycosaminoglycans from <i>Acipenser Baerii</i> Cartilage: Potential Regulation of Fibroblast Function Macromolecular Bioscience · 2026
    8. Fibroblasts as the subject of proliferative activity research in vitro Science and Innovations in Medicine · 2020 · 7 citations
    9. Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. Journal of Biological Chemistry · 1987 · 63 citations
    10. Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats Gene · 2015 · 42 citations
    11. Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing International Journal of Molecular Sciences · 2020 · 28 citations
    12. An epidermis‐permeable dipeptide is a potential cosmetic ingredient with partial agonist/antagonist activity toward fibroblast growth factor receptors Journal of Cosmetic Dermatology · 2019 · 3 citations
    13. Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in an<i>in vitro</i>organ culture system International Journal of Dermatology · 2007 · 7 citations
    14. Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts* 1983 · 57 citations
    15. Effects of the anti-androgen finasteride on 5alpha-reductase activity in human gingival fibroblasts in response to minocycline Journal of Clinical Periodontology · 1998 · 15 citations
    16. FINASTERIDE INHIBITS 5?-REDUCTASE ACTIVITY IN HUMAN DERMAL FIBROBLASTS: PREDICTION OF ITS THERAPEUTIC APPLICATION IN ANDROGEN-RELATED SKIN DISEASES International Journal of Dermatology · 1995 · 3 citations
    17. Effects of Polygoni Multiflori Radix on the Elastase, and Collagenase Activities and the Procollagen Synthesis in Hs68 Human Fibroblasts The Korea Journal of Herbology · 2014 · 2 citations
    18. Alkyl shikimates promote proliferation of human dermal fibroblasts and exhibit structure–activity relationships Scientific Reports · 2026
    19. Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways Cell Proliferation · 2025
    20. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations
    21. Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype PLOS genetics · 2019 · 24 citations
    22. The Antioxidant Activities and Hair-growth Promotion Effects of Tenebrio molitor Larvae Extracts (TMEs) JoLS Journal of Life Sciences · 2017 · 18 citations
    23. Investigation of Antioxidant Activity of Cynanchi Wilfordii Radix and Inhibitory Effect of 5α-reductase mRNA in Human Dermal Papilla Cells Dong-ui saengni byeongni hakoeji · 2017
    24. Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    25. β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010 · 314 citations
    26. Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing Theranostics · 2018 · 49 citations
    27. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors Scientific Reports · 2021 · 4 citations
    28. The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis Arthritis Research & Therapy · 2025
    29. Dermal fibroblasts in the focus of modern cosmetology: aging and response to cosmetic procedures: A review Consilium Medicum · 2024
    30. Fibroblast‐derived growth factors and exosomes as cosmeceuticals Dermatological reviews · 2023