3 citations
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May 2025 in “Lasers in Surgery and Medicine” This study suggested that MRF may support skin regeneration and rejuvenation by promoting collagen synthesis and regulating factors involved in fibroblast activation and ECM remodeling, with preliminary findings indicating ADSCs might aid these processes.
2 citations
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August 2022 in “Emergency medicine international” This study found that a key gene signature, including FGF11, highlights the immunologic nature of keloid lesions, distinguishing them from normal fibroblasts and scars.
17 citations
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September 2020 in “Inflammation and Regeneration” In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.
29 citations
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January 2010 in “Journal of oleo science” In this study, mannosylerythritol lipids from soybean oil notably increased fibroblast and papilla cell viability, suggesting potential as a hair growth agent.
June 2010 in “European Journal of Cancer Supplements” Senescent fibroblasts can help start tumors in normal skin cells.
115 citations
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February 2016 in “Nature Communications” The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.
June 2025 in “Food Science & Nutrition” This study found that peimine treatment significantly improved wound healing and tissue regeneration in mice by enhancing wound closure, granulation tissue formation, and epidermal thickness, with effects linked to activation of the Notch1 signaling pathway.
10 citations
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December 2018 in “Medical Science Monitor” This study suggests that the MAPK/ERK signaling pathway plays a role in the regulation of cell proliferation, apoptosis, and cycling in rat urethral plate fibroblasts affected by finasteride-induced hypospadias.
July 2025 in “Pharmaceutics” This study found that Annexin A5 significantly reduced fibrosis and inflammation in both preventive and therapeutic contexts in a bleomycin-induced localized scleroderma mouse model, demonstrating its potential anti-fibrotic and anti-inflammatory effects for treating fibrotic diseases.
4 citations
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June 2022 in “Journal of Cosmetic Dermatology” This study suggests that dermal fibroblast-conditioned medium containing multi-peptide factors may stimulate hair growth by enhancing growth factor expression and β-catenin regulation in hair follicle cells.
68 citations
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April 2012 in “Journal of Investigative Dermatology” The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.
February 2026 in “International Journal of Cosmetic Science” This study found that a novel Mito-Activator Complex, containing nicotinamide and epigallocatechin gallate, significantly increased hair density and growth in a 6-month human trial, with no adverse effects reported, potentially offering a new approach to hair loss treatment through mitochondrial activation.
36 citations
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March 2014 in “Annals of the Rheumatic Diseases” This study found that activating liver X receptors with an agonist reduced skin fibrosis in experimental models, particularly in inflammation-driven conditions, by inhibiting macrophage infiltration and interleukin-6 release.
119 citations
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November 2014 in “Trends in Cell Biology” This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.
April 2026 in “Research Square” E13 fetal mouse fibroblast vesicles may help reduce scarring.
January 2026 in “Current Issues in Molecular Biology” This paper reviews the emerging role of FGF-7 signaling in hair regeneration, highlighting its potential as a target for new therapies despite limited clinical trial data.
July 2024 in “Journal of Investigative Dermatology” PRP preparation partially activates platelets, causing varied growth factor release.
EGF and FGF signaling stops hair follicle development in mice.
87 citations
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January 2016 in “Development” This study suggests that the postnatal loss of hair follicle formation in wounds may be due to elevated Wnt/β-catenin activation in the dermis, affecting fibroblast function in mice.
April 2019 in “Journal of Investigative Dermatology” In this study, researchers found that canonical Wnt/β-catenin signaling and Wnt-ligand expression are distinctly regulated during wound healing across different cell populations and immunity conditions, particularly under type 2 immunity.
7 citations
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August 2023 in “Frontiers in Immunology” This review discusses the role of transient receptor potential channels in pathological scarification and suggests these channels as potential targets for its prevention and treatment, although it reports no new clinical findings.
This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.
January 2025 in “Archives of Dermatological Research” This research observed that Moracin M, a compound from the Moraceae family, significantly promotes hair growth and angiogenesis via the Wnt signaling pathway in human dermal papilla cells, offering a promising alternative to current hair growth treatments like minoxidil.
February 2019 in “Journal of Physiology & Pathology in Korean Medicine” In this study, the ethanol extract of Puerariae Radix was found to promote proliferation and ERK activation in human dermal fibroblasts, suggesting its potential as a new cosmetic ingredient.
August 2026 in “Scientific Reports” This study suggests that a Lentinula edodes extract can improve skin barrier function, hydration, and sebum regulation, possibly by modulating vitamin D pathways, in individuals with oily and acne-prone skin.
18 citations
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July 2023 in “International Journal of Molecular Sciences” This study found that KY19382, a small molecule activating the Wnt/β-catenin pathway, significantly improved wound healing by enhancing cell migration, increasing collagen and stem cell markers, and accelerating re-epithelialization and neo-epidermis formation in a murine model without causing significant cytotoxicity.
July 2026 in “Journal of Investigative Dermatology” ABS-201 may effectively promote hair growth in men by targeting the prolactin receptor.
July 2025 in “Journal of Investigative Dermatology” Laser treatment boosts hair growth by activating a key growth factor.
February 2024 in “Research Square (Research Square)” In this study, researchers found that exosomes derived from dermal papilla cells can enhance hair follicle regeneration during wound healing in nude mice by promoting fibroblast activation and stimulating the Wnt/β-catenin signaling pathway, suggesting their potential as a therapeutic strategy for regenerative skin healing.
128 citations
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October 2011 in “Development” This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.