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    Glossary Extracellular Matrix Remodeling

    continuous restructuring of the protein network outside cells

    Extracellular Matrix Remodeling (ECM Remodeling) refers to the dynamic process where the structure and composition of the extracellular matrix (a network of proteins and other molecules outside cells) are continuously broken down and rebuilt. This process is crucial for tissue development, wound healing, and maintaining healthy skin and hair, but it can also contribute to diseases like fibrosis and cancer if dysregulated.

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    1. Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model Lasers in Surgery and Medicine · 2025 · 3 citations
    2. A 3D-printed hydrogel scaffold promotes infected diabetic wound repair via anti-inflammation, angiogenesis, and extracellular matrix remodeling Materials & Design · 2026
    3. Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling International Journal of Molecular Sciences · 2026
    4. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    5. Mechano-encoding hydrogel microspheres for extracellular and pericellular matrix remodeling in musculoskeletal organoids Organoid Research · 2026
    6. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    7. Immunoguided cutaneous regeneration: a theoretical framework linking extracellular matrix, immunity, and skin allografts Frontiers in Immunology · 2026
    8. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    9. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation 2010 · 20 citations
    10. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000 · 42 citations
    11. Bioinspired Antibacterial-Antioxidant Bioactive Hydrogel Synchronizes Immunomodulation-Microenvironment Remodeling for Infected Wound Regeneration SSRN Electronic Journal · 2025
    12. Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure Scientific Reports · 2017 · 87 citations
    13. Programmable viscoelastic hydrogels exhibit antimicrobial and regenerative properties to promote cell migration, wound healing, and tissue remodeling Microsystems & Nanoengineering · 2026
    14. 866 Senescent fibroblasts secretome promote tumoural initiation of normal human keratinocytes through cellular activation, enhanced migration and ECM remodelling European Journal of Cancer Supplements · 2010
    15. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    16. Thymosin β<sub>4</sub>increases hair growth by activation of hair follicle stem cells The FASEB Journal · 2003 · 98 citations
    17. Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing Advanced Materials · 2025 · 21 citations
    18. Initial damage produced by a single 15-Gy x-ray irradiation to the rat calvaria skin European Radiology Experimental · 2020 · 9 citations
    19. The Therapeutic Role of ADSC-EVs in Skin Regeneration Frontiers in Medicine · 2022 · 7 citations
    20. Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways International Journal of Nanomedicine · 2025 · 5 citations
    21. Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis The FASEB Journal · 2024 · 3 citations
    22. Molecular mediators involved in skin healing: a narrative review F1000Research · 2022 · 3 citations
    23. Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives Pharmaceutics · 2025 · 2 citations
    24. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025 · 1 citations
    25. Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis Preprints.org · 2024 · 1 citations
    26. An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice ( <i>Acomys</i> ) Science Advances · 2023 · 1 citations
    27. Microbioreactor design for eukaryotic cell-based biomedical applications Frontiers in Bioengineering and Biotechnology · 2026
    28. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing Nutrients · 2026
    29. Advances in Tissue Bioengineering and Regenerative Aesthetic Medicine: Emerging Strategies for Tissue Restoration, Functional Recovery, and Personalized Healthcare International Science Journal · 2026
    30. PDO-Based Thread-Embedding Therapy for Hair Loss Management : Mechanistic Hypotheses Journal of Korea Society of Ingrielogy · 2026