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Finasteride exposure in pregnancy causes genital abnormalities in male rats.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Mouse genital development depends on male or female hormones for specific features.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Blocking a specific enzyme in male rat fetuses leads to the development of nipples and feminized genitalia.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

Conditions affecting sex development show that sexual diversity is a natural part of human variation.

Gene mutations can cause problems in male genital development.

Hair-Thread Tourniquet Syndrome is a rare condition where hair or thread tightly wraps around a child's body part, requiring quick treatment to prevent damage.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

A hair strand caused a rare case of limb strangulation in a teenage girl with autism, and the condition is not always linked to child abuse.

The document does not determine if adults with aphallia are fertile.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Finasteride use during early pregnancy may cause limb deformities in babies.

A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.

Diagnosing simple-virilizing congenital adrenal hyperplasia can be difficult and requires thorough testing and expert advice.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Hair-thread Tourniquet Syndrome, where hair or thread tightly wraps around a body part, is not rare and requires early detection to prevent serious damage.

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.