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    Glossary Epithelial Stem Cells

    cells that regenerate and repair skin and hair follicles

    Epithelial Stem Cells are a type of stem cell found in the epithelial tissues, which line the surfaces and cavities of organs and structures throughout the body, including the skin and hair follicles. These cells have the unique ability to self-renew and differentiate into various specialized cell types, playing a crucial role in tissue repair, regeneration, and maintaining the integrity of the epithelial layers.

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    1. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    2. Epithelial Stem Cells: Turning over New Leaves Cell · 2007 · 508 citations
    3. Plasticity of epithelial stem cells in tissue regeneration Science · 2014 · 479 citations
    4. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    5. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells Genes & development · 2005 · 384 citations
    6. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011 · 260 citations
    7. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche The Journal of Pathology · 2013 · 220 citations
    8. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006 · 176 citations
    9. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells Stem Cells · 2008 · 162 citations
    10. Epithelial stem cells and implications for wound repair Seminars in Cell & Developmental Biology · 2012 · 156 citations
    11. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    12. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    13. Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells Nature communications · 2014 · 99 citations
    14. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018 · 80 citations
    15. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    16. Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris Journal of Investigative Dermatology · 2017 · 71 citations
    17. New insights into the role of Runx1 in epithelial stem cell biology and pathology Journal of Cellular Biochemistry · 2012 · 63 citations
    18. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile ˜The œFASEB journal · 2007 · 45 citations
    19. Isolation of epithelial stem cells from dermis by a three-dimensional culture system Journal of Cellular Biochemistry · 2006 · 38 citations
    20. Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane Stem cell research & therapy · 2019 · 23 citations
    21. Transcriptional profiling of putative human epithelial stem cells BMC Genomics · 2008 · 16 citations
    22. Expansion and characterization of epithelial stem cells with potential for cyclical hair regeneration Scientific Reports · 2021 · 15 citations
    23. Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages Experimental Cell Research · 2014 · 14 citations
    24. N1-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles Archives of dermatological research · 2015 · 13 citations
    25. LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · 2021 · 10 citations
    26. The Epithelial Stem Cell Niche in Skin Elsevier eBooks · 2017 · 9 citations
    27. Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence Nature Communications · 2020 · 8 citations
    28. TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles Laboratory Investigation · 2016 · 7 citations
    29. Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells Biochemical Society Transactions · 2014 · 4 citations
    30. 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia Journal of Investigative Dermatology · 2022 · 1 citations