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    Glossary Epithelial Sac

    small, enclosed structure of epithelial cells around hair follicle

    An epithelial sac is a small, enclosed structure composed of epithelial cells, which are cells that line the surfaces and cavities of the body. In the context of hair biology, an epithelial sac can refer to the structure that surrounds the developing hair follicle, playing a crucial role in the formation and growth of hair. This sac provides a protective environment and supplies necessary nutrients to the growing hair shaft.

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    Research 30 of 1000+

    1. Treatment of Acne Scar Contraction Using Autologous Cultured Epithelial Sheet Transplantation: A Report of Four Cases Cureus · 2025
    2. Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    3. Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes Wound repair and regeneration · 2015 · 46 citations
    4. K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1 Journal of Investigative Dermatology · 2003 · 130 citations
    5. A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle Journal of Investigative Dermatology · 2002 · 86 citations
    6. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    7. Hair follicle-derived epithelial sheet has potential in vitiligo treatment medRxiv · 2026
    8. Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    9. Commentary on Clinical Application of Cultured Stratified Epithelial Sheets Grown Under Feeder or Feeder-Free Conditions for Stable Vitiligo Dermatologic Surgery · 2019
    10. Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration 2017 · 3 citations
    11. Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial–Mesenchymal Interactions 1999 · 92 citations
    12. ILK modulates epithelial polarity and matrix formation in hair follicles Molecular biology of the cell · 2013 · 22 citations
    13. Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression Nature cell biology · 2023 · 5 citations
    14. The Growth of Human Dermal Papilla Cells and Dermal Sheath Cells in Vitro Chinese Journal of Dermatology · 2001
    15. Sex Hormones and Antiandro Growth of Dermal Papilla H ens Influence In Vitro Ce Is and Outer Root Sheath Keratinocytes of Human Hair Follicles 1993
    16. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells Stem Cells · 2008 · 162 citations
    17. Fabrication and characterization of epithelial scaffolds for hair follicle regeneration Tissue Engineering and Regenerative Medicine · 2012 · 4 citations
    18. Original Article : Fabrication and Characterization of Epithelial Scaffolds for Hair Follicle Regeneration 조직공학과 재생의학 · 2012
    19. Manganese Ethylene Bis(Maneb)-Induced Degeneration of Hair Follicle Epithelia in the Dosal Skin of WBN/ILA-Ht Rats. Journal of Toxicologic Pathology · 1998 · 5 citations
    20. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles Differentiation · 1988 · 248 citations
    21. A Human Folliculoid Microsphere Assay for Exploring Epithelial– Mesenchymal Interactions in the Human Hair Follicle 2008 · 71 citations
    22. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    23. The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells Journal of Dermatological Science · 2001 · 47 citations
    24. Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts Journal of cutaneous pathology · 2008 · 43 citations
    25. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis Experimental Dermatology · 2008 · 22 citations
    26. Epithelial expression of the hormone leptin by bovine skin European journal of histochemistry · 2019 · 18 citations
    27. Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes Veterinary Dermatology · 2019 · 12 citations
    28. Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology bioRxiv (Cold Spring Harbor Laboratory) · 2026
    29. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    30. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations